Fields »
ABOUT
HELP
BLOG
FTO

CANCER ATLAS

Gene description

 Fat mass and obesity associated

Protein class

 Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041086

GENE INFORMATION

Gene name

 FTO (HGNC Symbol)

Synonyms

 ALKBH9, KIAA1752, MGC5149

Description

 Fat mass and obesity associated (HGNC Symbol)

Entrez gene summary

 This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]

Chromosome

 16

Cytoband

 q12.2

Chromosome location (bp)

 53703963 - 54121941

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140718 (version 83.38)

Entrez gene

 79068

UniProt

 Q9C0B1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9C0B1

Antibodypedia

 FTO antibodies

PROTEIN BROWSER
FTO-001
FTO-002
FTO-005
FTO-006
FTO-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FTO-001
ENSP00000418823
ENST00000471389
Q9C0B1 [Direct mapping]
Alpha-ketoglutarate-dependent dioxygenase FTO
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001659 [temperature homeostasis]
GO:0005634 [nucleus]
GO:0006307 [DNA dealkylation involved in DNA repair]
GO:0008198 [ferrous iron binding]
GO:0010883 [regulation of lipid storage]
GO:0016607 [nuclear speck]
GO:0035515 [oxidative RNA demethylase activity]
GO:0035516 [oxidative DNA demethylase activity]
GO:0035552 [oxidative single-stranded DNA demethylation]
GO:0035553 [oxidative single-stranded RNA demethylation]
GO:0040014 [regulation of multicellular organism growth]
GO:0042245 [RNA repair]
GO:0043734 [DNA-N1-methyladenine dioxygenase activity]
GO:0044065 [regulation of respiratory system process]
GO:0060612 [adipose tissue development]
GO:0070350 [regulation of white fat cell proliferation]
GO:0070989 [oxidative demethylation]
GO:0080111 [DNA demethylation]
Show all
 505 aa
58.3 kDa 		No 0
FTO-002
ENSP00000417422
ENST00000460382
Q9C0B1 [Direct mapping]
Alpha-ketoglutarate-dependent dioxygenase FTO
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006307 [DNA dealkylation involved in DNA repair]
GO:0008198 [ferrous iron binding]
GO:0016607 [nuclear speck]
GO:0035515 [oxidative RNA demethylase activity]
GO:0035516 [oxidative DNA demethylase activity]
GO:0035552 [oxidative single-stranded DNA demethylation]
GO:0035553 [oxidative single-stranded RNA demethylation]
GO:0042245 [RNA repair]
GO:0043734 [DNA-N1-methyladenine dioxygenase activity]
GO:0070989 [oxidative demethylation]
GO:0080111 [DNA demethylation]
Show all
 106 aa
12.2 kDa 		No 0
FTO-005
ENSP00000417843
ENST00000463855
Q9C0B1 [Direct mapping]
Alpha-ketoglutarate-dependent dioxygenase FTO
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006307 [DNA dealkylation involved in DNA repair]
GO:0008198 [ferrous iron binding]
GO:0016607 [nuclear speck]
GO:0035515 [oxidative RNA demethylase activity]
GO:0035516 [oxidative DNA demethylase activity]
GO:0035552 [oxidative single-stranded DNA demethylation]
GO:0035553 [oxidative single-stranded RNA demethylation]
GO:0042245 [RNA repair]
GO:0043734 [DNA-N1-methyladenine dioxygenase activity]
GO:0070989 [oxidative demethylation]
GO:0080111 [DNA demethylation]
Show all
 127 aa
14.9 kDa 		No 0
FTO-006
ENSP00000415636
ENST00000431610
Q9C0B1 [Direct mapping]
Alpha-ketoglutarate-dependent dioxygenase FTO
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006307 [DNA dealkylation involved in DNA repair]
GO:0008198 [ferrous iron binding]
GO:0016607 [nuclear speck]
GO:0035515 [oxidative RNA demethylase activity]
GO:0035516 [oxidative DNA demethylase activity]
GO:0035552 [oxidative single-stranded DNA demethylation]
GO:0035553 [oxidative single-stranded RNA demethylation]
GO:0042245 [RNA repair]
GO:0043734 [DNA-N1-methyladenine dioxygenase activity]
GO:0070989 [oxidative demethylation]
GO:0080111 [DNA demethylation]
Show all
 106 aa
12.2 kDa 		No 0
FTO-008
ENSP00000268349
ENST00000268349
X6R3I0 [Direct mapping]
Alpha-ketoglutarate-dependent dioxygenase FTO
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 129 aa
15 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.