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CHST4

GENERAL INFORMATION

Gene name

 CHST4

Gene description

 Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (gallbladder)
GTEx:Tissue enhanced (pancreas, liver)
FANTOM5:Tissue enriched (gallbladder)

Protein evidence

 Evidence at protein level

Protein expression

 Granular expression primarily in gallbladder but also in fallopian tube, pancreas and liver.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA021955
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (gallbladder)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (pancreas, liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (gallbladder)

GENE INFORMATION

Gene name

 CHST4 (HGNC Symbol)

Synonyms

 HEC-GLCNAC-6-ST, LSST

Description

 Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]

Chromosome

 16

Cytoband

 q22.2

Chromosome location (bp)

 71525233 - 71538746

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140835 (version 83.38)

Entrez gene

 10164

UniProt

 Q8NCG5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NCG5

Antibodypedia

 CHST4 antibodies

PROTEIN BROWSER
CHST4-001
CHST4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHST4-001
ENSP00000341206
ENST00000338482
Q8NCG5 [Direct mapping]
Carbohydrate sulfotransferase 4
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001517 [N-acetylglucosamine 6-O-sulfotransferase activity]
GO:0005802 [trans-Golgi network]
GO:0005975 [carbohydrate metabolic process]
GO:0006044 [N-acetylglucosamine metabolic process]
GO:0006477 [protein sulfation]
GO:0006790 [sulfur compound metabolic process]
GO:0006928 [movement of cell or subcellular component]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007155 [cell adhesion]
GO:0007267 [cell-cell signaling]
GO:0008146 [sulfotransferase activity]
GO:0016021 [integral component of membrane]
GO:0031228 [intrinsic component of Golgi membrane]
Show all
 386 aa
45.1 kDa 		Yes 0
CHST4-002
ENSP00000441204
ENST00000539698
Q8NCG5 [Direct mapping]
Carbohydrate sulfotransferase 4
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001517 [N-acetylglucosamine 6-O-sulfotransferase activity]
GO:0005802 [trans-Golgi network]
GO:0005975 [carbohydrate metabolic process]
GO:0006044 [N-acetylglucosamine metabolic process]
GO:0006477 [protein sulfation]
GO:0006790 [sulfur compound metabolic process]
GO:0006928 [movement of cell or subcellular component]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007155 [cell adhesion]
GO:0007267 [cell-cell signaling]
GO:0008146 [sulfotransferase activity]
GO:0016021 [integral component of membrane]
GO:0031228 [intrinsic component of Golgi membrane]
Show all
 386 aa
45.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.