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Head and neck cancers, several cervical, majority of urothelial cancers along with few prostate cancers showed moderate to strong nuclear positivity with additional cytoplasmic staining in few cases. Other cancers were weakly stained or negative.
GENE INFORMATION
Gene name
ZFHX3 (HGNC Symbol)
Synonyms
ATBF1, ZNF927
Description
Zinc finger homeobox 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Q15911 [Direct mapping] Zinc finger homeobox protein 3
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Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007050 [cell cycle arrest] GO:0007420 [brain development] GO:0007517 [muscle organ development] GO:0008270 [zinc ion binding] GO:0016604 [nuclear body] GO:0019899 [enzyme binding] GO:0032922 [circadian regulation of gene expression] GO:0043231 [intracellular membrane-bounded organelle] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045662 [negative regulation of myoblast differentiation] GO:0045663 [positive regulation of myoblast differentiation] GO:0045664 [regulation of neuron differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0071559 [response to transforming growth factor beta] GO:1904059 [regulation of locomotor rhythm]
Q15911 [Direct mapping] Zinc finger homeobox protein 3
Show all
Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007517 [muscle organ development] GO:0008270 [zinc ion binding] GO:0016604 [nuclear body] GO:0019899 [enzyme binding] GO:0032922 [circadian regulation of gene expression] GO:0043231 [intracellular membrane-bounded organelle] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045662 [negative regulation of myoblast differentiation] GO:0045663 [positive regulation of myoblast differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0071559 [response to transforming growth factor beta] GO:1904059 [regulation of locomotor rhythm]
