Cell atlas - CPNE2 - The Human Protein Atlas

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CPNE2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Mitochondria
	Nucleoplasm

Human cell
	Cytosol
	Mitochondria
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CPNE2
Gene description	Copine II
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol, mitochondria & nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Mitochondria (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA041132
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol, mitochondria & nucleoplasm.

Main location

Nucleoplasm (approved), Mitochondria (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA041132	A549	Nucleoplasm
			Mitochondria
			Cytosol
	HPA041132	U-2 OS	No staining
	HPA041132	U-251 MG	No staining

GENE INFORMATION
Gene name	CPNE2 (HGNC Symbol)
Synonyms	CPN2
Description	Copine II (HGNC Symbol)
Entrez gene summary	Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q13
Chromosome location (bp)	57092537 - 57148367
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140848 (version 83.38)
Entrez gene	221184
UniProt	Q96FN4 (UniProt - Evidence at protein level)
neXtProt	NX_Q96FN4
Antibodypedia	CPNE2 antibodies

PROTEIN BROWSER

CPNE2-001	CPNE2-002	CPNE2-003	CPNE2-007	CPNE2-008	CPNE2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPNE2-001 ENSP00000290776 ENST00000290776	Q96FN4 [Direct mapping] Copine-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0070062 [extracellular exosome] GO:0071277 [cellular response to calcium ion] Show all	548 aa 61.2 kDa	No	0
CPNE2-002 ENSP00000439018 ENST00000535318	Q96FN4 [Direct mapping] Copine-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0070062 [extracellular exosome] Show all	548 aa 61.2 kDa	No	0
CPNE2-003 ENSP00000456042 ENST00000565874	Q96FN4 [Direct mapping] Copine-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0070062 [extracellular exosome] Show all	548 aa 61.2 kDa	No	0
CPNE2-007 ENSP00000455443 ENST00000567487	H3BPR8 [Direct mapping] Copine-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	121 aa 13.6 kDa	No	0
CPNE2-008 ENSP00000455883 ENST00000566259	H3BQQ3 [Direct mapping] Copine-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	81 aa 8.8 kDa	No	0
CPNE2-009 ENSP00000457579 ENST00000565766	H3BUC8 [Direct mapping] Copine-2 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	281 aa 31.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.