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KATNB1

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GENERAL INFORMATION

Gene name

 KATNB1

Gene description

 Katanin p80 (WD repeat containing) subunit B 1

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the plasma membrane & cytosol. In addition localized to the microtubules.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (approved), Cytosol (supported)

Additional location

 In addition localized to the Microtubules (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA041165
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the plasma membrane & cytosol. In addition localized to the microtubules.

Main location

 Plasma membrane (approved), Cytosol (supported)

Additional location

 Microtubules (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA041165 A-431 Plasma membrane
Cytosol
HPA041165 U-2 OS Plasma membrane
Microtubules
Cytosol
HPA041165 U-251 MG Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 KATNB1

Synonyms

Description

 Katanin p80 (WD repeat containing) subunit B 1 (HGNC Symbol)

Entrez gene summary

 Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q21

Chromosome location (bp)

 57735730 - 57757250

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140854 (version 83.38)

Entrez gene

 10300

UniProt

 Q9BVA0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BVA0

Antibodypedia

 KATNB1 antibodies

PROTEIN BROWSER
KATNB1-001
KATNB1-003
KATNB1-004
KATNB1-005
KATNB1-008
KATNB1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KATNB1-001
ENSP00000368982
ENST00000379661
Q9BVA0 [Direct mapping]
Katanin p80 WD40 repeat-containing subunit B1
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006605 [protein targeting]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007079 [mitotic chromosome movement towards spindle pole]
GO:0008017 [microtubule binding]
GO:0008352 [katanin complex]
GO:0008568 [microtubule-severing ATPase activity]
GO:0010942 [positive regulation of cell death]
GO:0010976 [positive regulation of neuron projection development]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0030496 [midbody]
GO:0031117 [positive regulation of microtubule depolymerization]
GO:0043025 [neuronal cell body]
GO:0045502 [dynein binding]
GO:0046982 [protein heterodimerization activity]
GO:0051013 [microtubule severing]
GO:0051301 [cell division]
Show all
 655 aa
72.3 kDa 		No 0
KATNB1-003
ENSP00000455350
ENST00000562592
H3BPK1 [Direct mapping]
Katanin p80 WD40 repeat-containing subunit B1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008017 [microtubule binding]
GO:0008352 [katanin complex]
GO:0051013 [microtubule severing]
Show all
 210 aa
22.9 kDa 		No 0
KATNB1-004
ENSP00000457347
ENST00000566785
H3BTV8 [Direct mapping]
Katanin p80 WD40 repeat-containing subunit B1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008017 [microtubule binding]
GO:0008352 [katanin complex]
GO:0051013 [microtubule severing]
Show all
 79 aa
8.4 kDa 		No 0
KATNB1-005
ENSP00000457046
ENST00000569627
H3BT67 [Direct mapping]
Katanin p80 WD40 repeat-containing subunit B1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008017 [microtubule binding]
GO:0008352 [katanin complex]
GO:0051013 [microtubule severing]
Show all
 117 aa
12.4 kDa 		No 0
KATNB1-008
ENSP00000457334
ENST00000563462
H3BTU7 [Direct mapping]
Katanin p80 WD40 repeat-containing subunit B1
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 276 aa
30.1 kDa 		No 0
KATNB1-010
ENSP00000455270
ENST00000566726
H3BPD8 [Direct mapping]
Katanin p80 WD40 repeat-containing subunit B1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008017 [microtubule binding]
GO:0008352 [katanin complex]
GO:0051013 [microtubule severing]
Show all
 208 aa
22.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.