Expression of MAP1LC3B in cancer - Summary

CANCER ATLAS

Gene description

Microtubule-associated protein 1 light chain 3 beta

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Glioma

STAINING SUMMARY

HPA052474	HPA052484	HPA053767	CAB037216

GENE INFORMATION
Gene name	MAP1LC3B (HGNC Symbol)
Synonyms	ATG8F
Description	Microtubule-associated protein 1 light chain 3 beta (HGNC Symbol)
Entrez gene summary	The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q24.2
Chromosome location (bp)	87383995 - 87404779
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140941 (version 83.38)
Entrez gene	81631
UniProt	Q9GZQ8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9GZQ8
Antibodypedia	MAP1LC3B antibodies

PROTEIN BROWSER

MAP1LC3B-001	MAP1LC3B-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAP1LC3B-001 ENSP00000268607 ENST00000268607	Q9GZQ8 [Direct mapping] Microtubule-associated proteins 1A/1B light chain 3B Q658J6 [Target identity:100%; Query identity:100%] Microtubule-associated protein 1 light chain 3 beta, isoform CRA_c; Putative uncharacterized protein DKFZp762B153; cDNA FLJ77661, highly similar to Homo sapiens microtubule-associated protein 1 light chain 3 beta(MAP1LC3B), mRNA Show all	Predicted intracellular proteins Show all	GO:0000045 [autophagosome assembly] GO:0000407 [pre-autophagosomal structure] GO:0000421 [autophagosome membrane] GO:0000422 [mitophagy] GO:0000423 [macromitophagy] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005776 [autophagosome] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005930 [axoneme] GO:0006995 [cellular response to nitrogen starvation] GO:0008017 [microtubule binding] GO:0012505 [endomembrane system] GO:0016236 [macroautophagy] GO:0019898 [extrinsic component of membrane] GO:0031090 [organelle membrane] GO:0031410 [cytoplasmic vesicle] GO:0031625 [ubiquitin protein ligase binding] GO:0044804 [nucleophagy] GO:0061025 [membrane fusion] GO:1903146 [regulation of mitophagy] Show all	125 aa 14.7 kDa	No	0
MAP1LC3B-005 ENSP00000457225 ENST00000565788	H3BTL1 [Direct mapping] Microtubule-associated protein 1 light chain 3 beta, isoform CRA_f; Microtubule-associated proteins 1A/1B light chain 3B Show all	Predicted intracellular proteins Show all	GO:0000045 [autophagosome assembly] GO:0000407 [pre-autophagosomal structure] GO:0000421 [autophagosome membrane] GO:0000422 [mitophagy] GO:0005829 [cytosol] GO:0006995 [cellular response to nitrogen starvation] GO:0008017 [microtubule binding] GO:0019898 [extrinsic component of membrane] GO:0044804 [nucleophagy] GO:0061025 [membrane fusion] Show all	75 aa 9 kDa	No	0