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CDH13

GENERAL INFORMATION

Gene name

 CDH13

Gene description

 Cadherin 13

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (endometrium)
GTEx:Tissue enhanced (endometrium)
FANTOM5:Tissue enhanced (endometrium, cervix, uterine)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct membranous and cytoplasmic expression in muscle tissues, renal glomeruli, cerebral cortex, in endothelial cells and in basal cells of squamous epithelia.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA001380 , CAB025863
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (endometrium)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (endometrium)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (endometrium, cervix, uterine)

GENE INFORMATION

Gene name

 CDH13 (HGNC Symbol)

Synonyms

 CDHH

Description

 Cadherin 13 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]

Chromosome

 16

Cytoband

 q23.3

Chromosome location (bp)

 82626803 - 83800640

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140945 (version 83.38)

Entrez gene

 1012

UniProt

 P55290 (UniProt - Evidence at protein level)

neXtProt

 NX_P55290

Antibodypedia

 CDH13 antibodies

PROTEIN BROWSER
CDH13-001
CDH13-003
CDH13-004
CDH13-005
CDH13-007
CDH13-009
CDH13-201
CDH13-202
CDH13-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDH13-001
ENSP00000479395
ENST00000567109
P55290 [Direct mapping]
Cadherin-13
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0005509 [calcium ion binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007162 [negative regulation of cell adhesion]
GO:0007266 [Rho protein signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0016020 [membrane]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0016601 [Rac protein signal transduction]
GO:0030032 [lamellipodium assembly]
GO:0030100 [regulation of endocytosis]
GO:0030169 [low-density lipoprotein particle binding]
GO:0030335 [positive regulation of cell migration]
GO:0031225 [anchored component of membrane]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042058 [regulation of epidermal growth factor receptor signaling pathway]
GO:0043005 [neuron projection]
GO:0043542 [endothelial cell migration]
GO:0043616 [keratinocyte proliferation]
GO:0045216 [cell-cell junction organization]
GO:0045296 [cadherin binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0051668 [localization within membrane]
GO:0055096 [low-density lipoprotein particle mediated signaling]
GO:0055100 [adiponectin binding]
GO:0070062 [extracellular exosome]
GO:0071813 [lipoprotein particle binding]
Show all
 713 aa
78.3 kDa 		Yes 0
CDH13-003
ENSP00000408632
ENST00000431540
P55290 [Direct mapping]
Cadherin-13
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0005509 [calcium ion binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007162 [negative regulation of cell adhesion]
GO:0007266 [Rho protein signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0016020 [membrane]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0016601 [Rac protein signal transduction]
GO:0030032 [lamellipodium assembly]
GO:0030100 [regulation of endocytosis]
GO:0030169 [low-density lipoprotein particle binding]
GO:0030335 [positive regulation of cell migration]
GO:0031225 [anchored component of membrane]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042058 [regulation of epidermal growth factor receptor signaling pathway]
GO:0043005 [neuron projection]
GO:0043542 [endothelial cell migration]
GO:0043616 [keratinocyte proliferation]
GO:0045216 [cell-cell junction organization]
GO:0045296 [cadherin binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0051668 [localization within membrane]
GO:0055096 [low-density lipoprotein particle mediated signaling]
GO:0055100 [adiponectin binding]
GO:0070062 [extracellular exosome]
GO:0071813 [lipoprotein particle binding]
Show all
 190 aa
21.1 kDa 		Yes 0
CDH13-004
ENSP00000456491
ENST00000565636
P55290 [Direct mapping]
Cadherin-13
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0005509 [calcium ion binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007162 [negative regulation of cell adhesion]
GO:0007266 [Rho protein signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0016020 [membrane]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0016601 [Rac protein signal transduction]
GO:0030032 [lamellipodium assembly]
GO:0030100 [regulation of endocytosis]
GO:0030169 [low-density lipoprotein particle binding]
GO:0030335 [positive regulation of cell migration]
GO:0031225 [anchored component of membrane]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042058 [regulation of epidermal growth factor receptor signaling pathway]
GO:0043005 [neuron projection]
GO:0043542 [endothelial cell migration]
GO:0043616 [keratinocyte proliferation]
GO:0045216 [cell-cell junction organization]
GO:0045296 [cadherin binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0051668 [localization within membrane]
GO:0055096 [low-density lipoprotein particle mediated signaling]
GO:0055100 [adiponectin binding]
GO:0070062 [extracellular exosome]
GO:0071813 [lipoprotein particle binding]
Show all
 175 aa
19.7 kDa 		Yes 0
CDH13-005
ENSP00000394557
ENST00000428848
P55290 [Direct mapping]
Cadherin-13
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0005509 [calcium ion binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007162 [negative regulation of cell adhesion]
GO:0007266 [Rho protein signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0016020 [membrane]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0016601 [Rac protein signal transduction]
GO:0030032 [lamellipodium assembly]
GO:0030100 [regulation of endocytosis]
GO:0030169 [low-density lipoprotein particle binding]
GO:0030335 [positive regulation of cell migration]
GO:0031225 [anchored component of membrane]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042058 [regulation of epidermal growth factor receptor signaling pathway]
GO:0043005 [neuron projection]
GO:0043542 [endothelial cell migration]
GO:0043616 [keratinocyte proliferation]
GO:0045216 [cell-cell junction organization]
GO:0045296 [cadherin binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0051668 [localization within membrane]
GO:0055096 [low-density lipoprotein particle mediated signaling]
GO:0055100 [adiponectin binding]
GO:0070062 [extracellular exosome]
GO:0071813 [lipoprotein particle binding]
Show all
 674 aa
73.8 kDa 		Yes 0
CDH13-007
ENSP00000456297
ENST00000567445
H3BRL7 [Direct mapping]
Cadherin-13
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 67 aa
7.6 kDa 		Yes 0
CDH13-009
ENSP00000268613
ENST00000268613
P55290 [Direct mapping]
Cadherin-13
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007162 [negative regulation of cell adhesion]
GO:0007266 [Rho protein signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0009897 [external side of plasma membrane]
GO:0010033 [response to organic substance]
GO:0016020 [membrane]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0016601 [Rac protein signal transduction]
GO:0030032 [lamellipodium assembly]
GO:0030100 [regulation of endocytosis]
GO:0030169 [low-density lipoprotein particle binding]
GO:0030335 [positive regulation of cell migration]
GO:0031225 [anchored component of membrane]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042058 [regulation of epidermal growth factor receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0043542 [endothelial cell migration]
GO:0043616 [keratinocyte proliferation]
GO:0045216 [cell-cell junction organization]
GO:0045296 [cadherin binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0051668 [localization within membrane]
GO:0055096 [low-density lipoprotein particle mediated signaling]
GO:0055100 [adiponectin binding]
GO:0070062 [extracellular exosome]
GO:0071813 [lipoprotein particle binding]
Show all
 760 aa
83.4 kDa 		No 0
CDH13-201
ENSP00000454435
ENST00000566620
A0A0A0MTR1 [Direct mapping]
Cadherin-13
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0016020 [membrane]
Show all
 701 aa
77 kDa 		No 0
CDH13-202
ENSP00000482651
ENST00000615627
A0A087WZG7 [Direct mapping]
Cadherin-13
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 353 aa
38.4 kDa 		No 0
CDH13-203
ENSP00000483719
ENST00000622885
A0A087X0X6 [Direct mapping]
Cadherin-13
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0016020 [membrane]
Show all
 661 aa
72.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.