We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most malignant lymphomas showed strong nuclear staining, while some malignant melanomas displayed moderate cytoplasmic positivity. Remaining normal and malignant cells were in general weakly stained or negative.
Colorectal cancers exhibited moderate nuclear positivity whereas strong nuclear immunoreactivity was observed in most malignant lymphomas and a few cases of gastric cancers. Remaining malignant cells were generally negative.
GENE INFORMATION
Gene name
IRF8 (HGNC Symbol)
Synonyms
ICSBP, ICSBP1, IRF-8
Description
Interferon regulatory factor 8 (HGNC Symbol)
Entrez gene summary
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000975 [regulatory region DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006909 [phagocytosis] GO:0006955 [immune response] GO:0009617 [response to bacterium] GO:0019221 [cytokine-mediated signaling pathway] GO:0030099 [myeloid cell differentiation] GO:0032729 [positive regulation of interferon-gamma production] GO:0032735 [positive regulation of interleukin-12 production] GO:0042742 [defense response to bacterium] GO:0042832 [defense response to protozoan] GO:0044130 [negative regulation of growth of symbiont in host] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0060261 [positive regulation of transcription initiation from RNA polymerase II promoter] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071222 [cellular response to lipopolysaccharide]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated]
