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Most cancer tissues exhibited weak to moderate cytoplasmic immunoreactivity. Papillary adenocarcinomas of thyroid along with several testicular cancers were negative.
Malignancies generally showed moderate cytoplasmic staining. Strong positivity was observed in a few cases, mainly in testicular cancer. One example of cholangiocarcinoma displayed few nuclei with a rod-like staining pattern.
GENE INFORMATION
Gene name
PDPK1 (HGNC Symbol)
Synonyms
PDK1
Description
3-phosphoinositide dependent protein kinase 1 (HGNC Symbol)
O15530 [Direct mapping] 3-phosphoinositide-dependent protein kinase 1
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
O15530 [Direct mapping] 3-phosphoinositide-dependent protein kinase 1
Show all
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)