Expression of GALNS in cancer - Summary

CANCER ATLAS

Gene description

Galactosamine (N-acetyl)-6-sulfatase

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB026404

GENE INFORMATION
Gene name	GALNS (HGNC Symbol)
Synonyms	GALNAC6S, GAS
Description	Galactosamine (N-acetyl)-6-sulfatase (HGNC Symbol)
Entrez gene summary	This gene encodes N-acetylgalactosamine-6-sulfatase which is a lysosomal exohydrolase required for the degradation of the glycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate. Sequence alterations including point, missense and nonsense mutations, as well as those that affect splicing, result in a deficiency of this enzyme. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q24.3
Chromosome location (bp)	88813734 - 88856970
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141012 (version 83.38)
Entrez gene	2588
UniProt	P34059 (UniProt - Evidence at protein level)
neXtProt	NX_P34059
Antibodypedia	GALNS antibodies

PROTEIN BROWSER

GALNS-001	GALNS-002	GALNS-008	GALNS-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GALNS-001 ENSP00000268695 ENST00000268695	P34059 [Direct mapping] N-acetylgalactosamine-6-sulfatase Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003943 [N-acetylgalactosamine-4-sulfatase activity] GO:0005975 [carbohydrate metabolic process] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] GO:0030203 [glycosaminoglycan metabolic process] GO:0042339 [keratan sulfate metabolic process] GO:0042340 [keratan sulfate catabolic process] GO:0043202 [lysosomal lumen] GO:0043890 [N-acetylgalactosamine-6-sulfatase activity] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	522 aa 58 kDa	Yes	0
GALNS-002 ENSP00000455006 ENST00000568311	H3BNU2 [Direct mapping] N-acetylgalactosamine-6-sulfatase Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		116 aa 12.3 kDa	Yes	0
GALNS-008 ENSP00000456884 ENST00000569433	H3BSU9 [Direct mapping] N-acetylgalactosamine-6-sulfatase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		78 aa 8.2 kDa	Yes	0
GALNS-009 ENSP00000455174 ENST00000562831	H3BP66 [Direct mapping] N-acetylgalactosamine-6-sulfatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] Show all	170 aa 19.4 kDa	No	0