Cell atlas - MED9 - The Human Protein Atlas

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MED9

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Midbody
	Nucleoplasm

Human cell
	Microtubules
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MED9
Gene description	Mediator complex subunit 9
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the midbody.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Midbody (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA056415
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the midbody.

Main location

Nucleoplasm (approved)

Additional location

Midbody (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA056415	A549	Nucleoplasm
	HPA056415	CACO-2	Nucleoplasm
	HPA056415	CACO-2	Midbody	Intensity	Intensity
	HPA056415	U-2 OS	Nucleoplasm

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition

GENE INFORMATION
Gene name	MED9 (HGNC Symbol)
Synonyms	FLJ10193, MED25
Description	Mediator complex subunit 9 (HGNC Symbol)
Entrez gene summary	The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	17476986 - 17493226
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141026 (version 83.38)
Entrez gene	55090
UniProt	Q9NWA0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NWA0
Antibodypedia	MED9 antibodies

PROTEIN BROWSER

MED9-001	MED9-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MED9-001 ENSP00000268711 ENST00000268711	Q9NWA0 [Direct mapping] Mediator of RNA polymerase II transcription subunit 9 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0005515 [protein binding] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	146 aa 16.4 kDa	No	0
MED9-002 ENSP00000463031 ENST00000580462	J3KTK5 [Direct mapping] Mediator complex subunit 9; Mediator of RNA polymerase II transcription subunit 9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		82 aa 8.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.