Cell atlas - VPS53 - The Human Protein Atlas

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VPS53

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Golgi apparatus

Human cell
	Cytosol
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	VPS53
Gene description	Vacuolar protein sorting 53 homolog (S. cerevisiae)
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & the Golgi apparatus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (supported), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA024446
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & the Golgi apparatus.

Main location

Golgi apparatus (supported), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA024446	U-2 OS	Golgi apparatus
	HPA024446	U-2 OS	Cytosol
	HPA024446	U-251 MG	Golgi apparatus
	HPA024446	U-251 MG	Cytosol

GENE INFORMATION
Gene name	VPS53 (HGNC Symbol)
Synonyms	FLJ10979, HCCS1
Description	Vacuolar protein sorting 53 homolog (S. cerevisiae) (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with sequence similarity to the yeast Vps53p protein. Vps53p is involved in retrograde vesicle trafficking in late Golgi. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p13.3
Chromosome location (bp)	508668 - 721717
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141252 (version 83.38)
Entrez gene	55275
UniProt	Q5VIR6 (UniProt - Evidence at protein level)
neXtProt	NX_Q5VIR6
Antibodypedia	VPS53 antibodies

PROTEIN BROWSER

VPS53-001	VPS53-002	VPS53-003	VPS53-006	VPS53-011	VPS53-019	VPS53-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VPS53-001 ENSP00000401435 ENST00000437048	Q5VIR6 [Direct mapping] Vacuolar protein sorting-associated protein 53 homolog Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000938 [GARP complex] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0010008 [endosome membrane] GO:0015031 [protein transport] GO:0032456 [endocytic recycling] GO:0042147 [retrograde transport, endosome to Golgi] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:1990745 [EARP complex] Show all	832 aa 94.4 kDa	No	0
VPS53-002 ENSP00000291074 ENST00000291074	Q5VIR6 [Direct mapping] Vacuolar protein sorting-associated protein 53 homolog Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000938 [GARP complex] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0010008 [endosome membrane] GO:0015031 [protein transport] GO:0032456 [endocytic recycling] GO:0042147 [retrograde transport, endosome to Golgi] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:1990745 [EARP complex] Show all	670 aa 76.4 kDa	No	0
VPS53-003 ENSP00000384294 ENST00000401468	E7EVT8 [Direct mapping] Vacuolar protein sorting-associated protein 53 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0042147 [retrograde transport, endosome to Golgi] Show all	422 aa 47.6 kDa	No	0
VPS53-006 ENSP00000459312 ENST00000571805	Q5VIR6 [Direct mapping] Vacuolar protein sorting-associated protein 53 homolog Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000938 [GARP complex] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0010008 [endosome membrane] GO:0015031 [protein transport] GO:0032456 [endocytic recycling] GO:0042147 [retrograde transport, endosome to Golgi] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:1990745 [EARP complex] Show all	699 aa 79.7 kDa	No	0
VPS53-011 ENSP00000461429 ENST00000576019	I3L4P9 [Direct mapping] Vacuolar protein sorting-associated protein 53 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0042147 [retrograde transport, endosome to Golgi] Show all	68 aa 7.9 kDa	No	0
VPS53-019 ENSP00000458651 ENST00000570650	I3L184 [Direct mapping] Vacuolar protein sorting-associated protein 53 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0042147 [retrograde transport, endosome to Golgi] Show all	237 aa 27.2 kDa	No	0
VPS53-020 ENSP00000459159 ENST00000574029	I3L1W6 [Direct mapping] Vacuolar protein sorting-associated protein 53 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0042147 [retrograde transport, endosome to Golgi] Show all	145 aa 16.4 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.