Cell atlas - G6PC3 - The Human Protein Atlas

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G6PC3

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	G6PC3
Gene description	Glucose 6 phosphatase, catalytic, 3
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA067052
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA067052	PC-3	Endoplasmic reticulum

GENE INFORMATION
Gene name	G6PC3 (HGNC Symbol)
Synonyms	UGRP
Description	Glucose 6 phosphatase, catalytic, 3 (HGNC Symbol)
Entrez gene summary	This gene encodes the catalytic subunit of glucose-6-phosphatase (G6Pase). G6Pase is located in the endoplasmic reticulum (ER) and catalyzes the hydrolysis of glucose-6-phosphate to glucose and phosphate in the last step of the gluconeogenic and glycogenolytic pathways. Mutations in this gene result in autosomal recessive severe congenital neutropenia. Multiple transcript variants have been found for this gene, only one of which is expected to express a protein.[provided by RefSeq, Sep 2009]
Chromosome	17
Cytoband	q21.31
Chromosome location (bp)	44070735 - 44076344
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141349 (version 83.38)
Entrez gene	92579
UniProt	Q9BUM1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BUM1
Antibodypedia	G6PC3 antibodies

PROTEIN BROWSER

G6PC3-001	G6PC3-004	G6PC3-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
G6PC3-001 ENSP00000269097 ENST00000269097	Q9BUM1 [Direct mapping] Glucose-6-phosphatase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004346 [glucose-6-phosphatase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005975 [carbohydrate metabolic process] GO:0006094 [gluconeogenesis] GO:0006796 [phosphate-containing compound metabolic process] GO:0008645 [hexose transport] GO:0015758 [glucose transport] GO:0015760 [glucose-6-phosphate transport] GO:0016020 [membrane] GO:0016311 [dephosphorylation] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0044281 [small molecule metabolic process] GO:0051156 [glucose 6-phosphate metabolic process] GO:0055085 [transmembrane transport] Show all	346 aa 38.7 kDa	No	9
G6PC3-004 ENSP00000465111 ENST00000590253	K7EJC5 [Direct mapping] Glucose-6-phosphatase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006094 [gluconeogenesis] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0051156 [glucose 6-phosphate metabolic process] Show all	69 aa 7.2 kDa	No	0
G6PC3-007 ENSP00000468677 ENST00000591696	K7ESE6 [Direct mapping] Glucose-6-phosphatase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006094 [gluconeogenesis] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0051156 [glucose 6-phosphate metabolic process] Show all	243 aa 27.6 kDa	No	5

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.