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TAF4B

GENERAL INFORMATION

Gene name

 TAF4B

Gene description

 TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA028937
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TAF4B (HGNC Symbol)

Synonyms

 TAF2C2, TAFII105

Description

 TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa (HGNC Symbol)

Entrez gene summary

 TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Chromosome

 18

Cytoband

 q11.2

Chromosome location (bp)

 26225936 - 26391685

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141384 (version 83.38)

Entrez gene

 6875

UniProt

 Q92750 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92750

Antibodypedia

 TAF4B antibodies

PROTEIN BROWSER
TAF4B-001
TAF4B-002
TAF4B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TAF4B-001
ENSP00000462980
ENST00000578121
J3KTH2 [Direct mapping]
HCG38478, isoform CRA_a; Transcription initiation factor TFIID subunit 4B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005654 [nucleoplasm]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
GO:2000648 [positive regulation of stem cell proliferation]
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 867 aa
91.7 kDa 		No 0
TAF4B-002
ENSP00000269142
ENST00000269142
Q92750 [Direct mapping]
Transcription initiation factor TFIID subunit 4B
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005654 [nucleoplasm]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0007283 [spermatogenesis]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0046982 [protein heterodimerization activity]
GO:0048477 [oogenesis]
GO:0051059 [NF-kappaB binding]
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 862 aa
91.1 kDa 		No 0
TAF4B-201
ENSP00000383314
ENST00000400466
A0A0A0MSA8 [Direct mapping]
Transcription initiation factor TFIID subunit 4B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005669 [transcription factor TFIID complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
Show all
 865 aa
91.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.