Expression of AFG3L2 in cancer - Summary

CANCER ATLAS

Gene description

AFG3-like AAA ATPase 2

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA004479	HPA004480

GENE INFORMATION
Gene name	AFG3L2 (HGNC Symbol)
Synonyms	SCA28, SPAX5
Description	AFG3-like AAA ATPase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders. [provided by RefSeq, Jul 2008]
Chromosome	18
Cytoband	p11.21
Chromosome location (bp)	12328944 - 12377314
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141385 (version 83.38)
Entrez gene	10939
UniProt	Q9Y4W6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y4W6
Antibodypedia	AFG3L2 antibodies

PROTEIN BROWSER

AFG3L2-001	AFG3L2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AFG3L2-001 ENSP00000269143 ENST00000269143	Q9Y4W6 [Direct mapping] AFG3-like protein 2 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006508 [proteolysis] GO:0007005 [mitochondrion organization] GO:0007409 [axonogenesis] GO:0007528 [neuromuscular junction development] GO:0008053 [mitochondrial fusion] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0021675 [nerve development] GO:0034982 [mitochondrial protein processing] GO:0040014 [regulation of multicellular organism growth] GO:0042407 [cristae formation] GO:0042552 [myelination] GO:0048747 [muscle fiber development] GO:0051082 [unfolded protein binding] GO:0060013 [righting reflex] Show all	797 aa 88.6 kDa	No	2
AFG3L2-002 ENSP00000467236 ENST00000590811	K7EP56 [Direct mapping] AFG3-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005524 [ATP binding] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	209 aa 23.5 kDa	No	2