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GNAL

GENERAL INFORMATION

Gene name

 GNAL

Gene description

 Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Group enriched (caudate, pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
CAB015464
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, pituitary gland)

GENE INFORMATION

Gene name

 GNAL

Synonyms

Description

 Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type (HGNC Symbol)

Entrez gene summary

 This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutations in this gene have been associated with dystonia 25 and this gene is located in a susceptibility region for bipolar disorder and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Chromosome

 18

Cytoband

 p11.21

Chromosome location (bp)

 11688956 - 11885685

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141404 (version 83.38)

Entrez gene

 2774

UniProt

 P38405 (UniProt - Evidence at protein level)

neXtProt

 NX_P38405

Antibodypedia

 GNAL antibodies

PROTEIN BROWSER
GNAL-001
GNAL-002
GNAL-004
GNAL-005
GNAL-006
GNAL-008
GNAL-009
GNAL-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNAL-001
ENSP00000334051
ENST00000334049
P38405 [Direct mapping]
Guanine nucleotide-binding protein G(olf) subunit alpha
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0001975 [response to amphetamine]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005525 [GTP binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007608 [sensory perception of smell]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031000 [response to caffeine]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 458 aa
52.5 kDa 		No 0
GNAL-002
ENSP00000408489
ENST00000423027
P38405 [Direct mapping]
Guanine nucleotide-binding protein G(olf) subunit alpha
A8K1Y9 [Target identity:100%; Query identity:100%]
Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type, isoform CRA_b; cDNA FLJ78702, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type (GNAL), transcript variant 2, mRNA; cDNA, FLJ94539, Homo sapiens guanine nucleotide binding protein (G protein), alphaactivating activity polypeptide, olfactory type (GNAL), transcriptvariant 2, mRNA
Show all
Predicted intracellular proteins
Disease related genes
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005525 [GTP binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007608 [sensory perception of smell]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 381 aa
44.3 kDa 		No 0
GNAL-004
ENSP00000269162
ENST00000269162
P38405 [Direct mapping]
Guanine nucleotide-binding protein G(olf) subunit alpha
A8K1Y9 [Target identity:100%; Query identity:100%]
Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type, isoform CRA_b; cDNA FLJ78702, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type (GNAL), transcript variant 2, mRNA; cDNA, FLJ94539, Homo sapiens guanine nucleotide binding protein (G protein), alphaactivating activity polypeptide, olfactory type (GNAL), transcriptvariant 2, mRNA
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005525 [GTP binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007608 [sensory perception of smell]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 381 aa
44.3 kDa 		No 0
GNAL-005
ENSP00000439023
ENST00000535121
P38405 [Direct mapping]
Guanine nucleotide-binding protein G(olf) subunit alpha
A8K1Y9 [Target identity:100%; Query identity:100%]
Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type, isoform CRA_b; cDNA FLJ78702, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type (GNAL), transcript variant 2, mRNA; cDNA, FLJ94539, Homo sapiens guanine nucleotide binding protein (G protein), alphaactivating activity polypeptide, olfactory type (GNAL), transcriptvariant 2, mRNA
Show all
Predicted intracellular proteins
Disease related genes
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005525 [GTP binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007608 [sensory perception of smell]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 381 aa
44.3 kDa 		No 0
GNAL-006
ENSP00000473600
ENST00000602628
P38405 [Direct mapping]
Guanine nucleotide-binding protein G(olf) subunit alpha
Show all
Predicted intracellular proteins
Disease related genes
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005525 [GTP binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007608 [sensory perception of smell]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 174 aa
20.5 kDa 		No 0
GNAL-008
ENSP00000467345
ENST00000585642
K7EPE2 [Direct mapping]
Guanine nucleotide-binding protein G(olf) subunit alpha
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005525 [GTP binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007608 [sensory perception of smell]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
Show all
 179 aa
20.9 kDa 		No 0
GNAL-009
ENSP00000467709
ENST00000590228
K7EQ80 [Direct mapping]
Guanine nucleotide-binding protein G(olf) subunit alpha
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005525 [GTP binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007608 [sensory perception of smell]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
Show all
 145 aa
17 kDa 		No 0
GNAL-011
ENSP00000466709
ENST00000586926
K7EMY6 [Direct mapping]
Guanine nucleotide-binding protein G(olf) subunit alpha
Show all
Predicted intracellular proteins
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007608 [sensory perception of smell]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
Show all
 54 aa
6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.