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Breast cancers exhibited moderate to strong immunoreactivity while many cases of malignant melanomas, colorectal, prostate and testicular cancers showed moderate staining. Malignant cells in general were weakly stained in the cytoplasm or negative. Additional nuclear positivity was observed in squamous cell carcinomas, testicular and urothelial cancers.
GENE INFORMATION
Gene name
SLC39A6 (HGNC Symbol)
Synonyms
LIV-1
Description
Solute carrier family 39 (zinc transporter), member 6 (HGNC Symbol)
Entrez gene summary
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]