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GALNT1

GENERAL INFORMATION

Gene name

 GALNT1

Gene description

 Polypeptide N-acetylgalactosaminyltransferase 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic and nuclear membranous expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Uncertain based on 1 antibody.
HPA012628
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GALNT1 (HGNC Symbol)

Synonyms

 GalNAc-T1

Description

 Polypeptide N-acetylgalactosaminyltransferase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. Transcript variants derived from this gene that utilize alternative polyA signals have been described in the literature. [provided by RefSeq, Jul 2008]

Chromosome

 18

Cytoband

 q12.2

Chromosome location (bp)

 35581117 - 35711834

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141429 (version 83.38)

Entrez gene

 2589

UniProt

 Q10472 (UniProt - Evidence at protein level)

neXtProt

 NX_Q10472

Antibodypedia

 GALNT1 antibodies

PROTEIN BROWSER
GALNT1-001
GALNT1-002
GALNT1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GALNT1-001
ENSP00000269195
ENST00000269195
Q10472 [Direct mapping]
Polypeptide N-acetylgalactosaminyltransferase 1 Polypeptide N-acetylgalactosaminyltransferase 1 soluble form
A0A024RC48 [Target identity:100%; Query identity:100%]
Polypeptide N-acetylgalactosaminyltransferase
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0004653 [polypeptide N-acetylgalactosaminyltransferase activity]
GO:0005576 [extracellular region]
GO:0005794 [Golgi apparatus]
GO:0006493 [protein O-linked glycosylation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0018242 [protein O-linked glycosylation via serine]
GO:0018243 [protein O-linked glycosylation via threonine]
GO:0030145 [manganese ion binding]
GO:0030246 [carbohydrate binding]
GO:0032580 [Golgi cisterna membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 559 aa
64.2 kDa 		No 1
GALNT1-002
ENSP00000466411
ENST00000591081
Q10472 [Direct mapping]
Polypeptide N-acetylgalactosaminyltransferase 1 Polypeptide N-acetylgalactosaminyltransferase 1 soluble form
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0004653 [polypeptide N-acetylgalactosaminyltransferase activity]
GO:0005576 [extracellular region]
GO:0005794 [Golgi apparatus]
GO:0006493 [protein O-linked glycosylation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0018242 [protein O-linked glycosylation via serine]
GO:0018243 [protein O-linked glycosylation via threonine]
GO:0030145 [manganese ion binding]
GO:0030246 [carbohydrate binding]
GO:0032580 [Golgi cisterna membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 105 aa
12 kDa 		No 0
GALNT1-006
ENSP00000465699
ENST00000591924
Q10472 [Direct mapping]
Polypeptide N-acetylgalactosaminyltransferase 1 Polypeptide N-acetylgalactosaminyltransferase 1 soluble form
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0004653 [polypeptide N-acetylgalactosaminyltransferase activity]
GO:0005576 [extracellular region]
GO:0005794 [Golgi apparatus]
GO:0006493 [protein O-linked glycosylation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0018242 [protein O-linked glycosylation via serine]
GO:0018243 [protein O-linked glycosylation via threonine]
GO:0030145 [manganese ion binding]
GO:0030246 [carbohydrate binding]
GO:0032580 [Golgi cisterna membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 105 aa
12 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.