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GAREM

GENERAL INFORMATION

Gene name

 GAREM

Gene description

 GRB2 associated, regulator of MAPK1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA040709 , HPA042046
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 GAREM (HGNC Symbol)

Synonyms

 C18orf11, FAM59A, FLJ21610

Description

 GRB2 associated, regulator of MAPK1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an adaptor protein which functions in the epidermal growth factor (EGF) receptor-mediated signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 18

Cytoband

 q12.1

Chromosome location (bp)

 32124877 - 32470484

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141441 (version 83.38)

Entrez gene

 64762

UniProt

 Q9H706 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H706

Antibodypedia

 GAREM antibodies

PROTEIN BROWSER
GAREM-001
GAREM-002
GAREM-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GAREM-001
ENSP00000382165
ENST00000399218
Q9H706 [Direct mapping]
GRB2-associated and regulator of MAPK protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0051781 [positive regulation of cell division]
GO:0070064 [proline-rich region binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071364 [cellular response to epidermal growth factor stimulus]
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 875 aa
97.1 kDa 		No 0
GAREM-002
ENSP00000269209
ENST00000269209
Q9H706 [Direct mapping]
GRB2-associated and regulator of MAPK protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0051781 [positive regulation of cell division]
GO:0070064 [proline-rich region binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071364 [cellular response to epidermal growth factor stimulus]
Show all
 876 aa
97.2 kDa 		No 0
GAREM-004
ENSP00000464185
ENST00000583696
J3QRF3 [Direct mapping]
GRB2-associated and regulator of MAPK protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 36 aa
3.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.