Cell atlas - OSBPL1A - The Human Protein Atlas

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OSBPL1A

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	OSBPL1A
Gene description	Oxysterol binding protein-like 1A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (uncertain), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA043401
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol.

Main location

Nucleoplasm (uncertain), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA043401	A-431	Nucleoplasm
	HPA043401	A-431	Cytosol
	HPA043401	U-251 MG	Nucleoplasm
	HPA043401	U-251 MG	Cytosol

GENE INFORMATION
Gene name	OSBPL1A (HGNC Symbol)
Synonyms	ORP-1, ORP1, OSBPL1B
Description	Oxysterol binding protein-like 1A (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	18
Cytoband	q11.2
Chromosome location (bp)	24162044 - 24397880
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141447 (version 83.38)
Entrez gene	114876
UniProt	Q9BXW6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BXW6
Antibodypedia	OSBPL1A antibodies

PROTEIN BROWSER

OSBPL1A-001	OSBPL1A-002	OSBPL1A-003	OSBPL1A-005	OSBPL1A-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OSBPL1A-001 ENSP00000320291 ENST00000319481	Q9BXW6 [Direct mapping] Oxysterol-binding protein-related protein 1 B0YJ56 [Target identity:100%; Query identity:100%] Oxysterol-binding protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005765 [lysosomal membrane] GO:0005770 [late endosome] GO:0006869 [lipid transport] GO:0008203 [cholesterol metabolic process] GO:0015485 [cholesterol binding] GO:0016192 [vesicle-mediated transport] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0070062 [extracellular exosome] Show all	950 aa 108.5 kDa	No	0
OSBPL1A-002 ENSP00000382372 ENST00000399443	Q9BXW6 [Direct mapping] Oxysterol-binding protein-related protein 1 Q6GSK5 [Target identity:100%; Query identity:100%] Oxysterol-binding protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005765 [lysosomal membrane] GO:0005770 [late endosome] GO:0006869 [lipid transport] GO:0008203 [cholesterol metabolic process] GO:0015485 [cholesterol binding] GO:0016192 [vesicle-mediated transport] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0070062 [extracellular exosome] Show all	437 aa 50.3 kDa	No	0
OSBPL1A-003 ENSP00000349545 ENST00000357041	Q9BXW6 [Direct mapping] Oxysterol-binding protein-related protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005765 [lysosomal membrane] GO:0005770 [late endosome] GO:0006869 [lipid transport] GO:0008203 [cholesterol metabolic process] GO:0015485 [cholesterol binding] GO:0016192 [vesicle-mediated transport] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0070062 [extracellular exosome] Show all	568 aa 65.1 kDa	No	0
OSBPL1A-005 ENSP00000382370 ENST00000399441	E7ER58 [Direct mapping] Oxysterol-binding protein-related protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	100 aa 11.1 kDa	No	0
OSBPL1A-017 ENSP00000464617 ENST00000578013	J3QSB8 [Direct mapping] Oxysterol-binding protein-related protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		285 aa 33 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.