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This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012]
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001701 [in utero embryonic development] GO:0001889 [liver development] GO:0003148 [outflow tract septum morphogenesis] GO:0003309 [type B pancreatic cell differentiation] GO:0003310 [pancreatic A cell differentiation] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006644 [phospholipid metabolic process] GO:0007493 [endodermal cell fate determination] GO:0007596 [blood coagulation] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008584 [male gonad development] GO:0010468 [regulation of gene expression] GO:0014898 [cardiac muscle hypertrophy in response to stress] GO:0019901 [protein kinase binding] GO:0030513 [positive regulation of BMP signaling pathway] GO:0030855 [epithelial cell differentiation] GO:0031016 [pancreas development] GO:0032911 [negative regulation of transforming growth factor beta1 production] GO:0032912 [negative regulation of transforming growth factor beta2 production] GO:0035239 [tube morphogenesis] GO:0035987 [endodermal cell differentiation] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0043627 [response to estrogen] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045165 [cell fate commitment] GO:0045766 [positive regulation of angiogenesis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048468 [cell development] GO:0048645 [organ formation] GO:0048738 [cardiac muscle tissue development] GO:0051145 [smooth muscle cell differentiation] GO:0051891 [positive regulation of cardioblast differentiation] GO:0055007 [cardiac muscle cell differentiation] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0060430 [lung saccule development] GO:0060486 [Clara cell differentiation] GO:0060510 [Type II pneumocyte differentiation] GO:0060575 [intestinal epithelial cell differentiation] GO:0060947 [cardiac vascular smooth muscle cell differentiation] GO:0070848 [response to growth factor] GO:0071158 [positive regulation of cell cycle arrest] GO:0071371 [cellular response to gonadotropin stimulus] GO:0071456 [cellular response to hypoxia] GO:0071773 [cellular response to BMP stimulus]
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003148 [outflow tract septum morphogenesis] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007596 [blood coagulation] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008584 [male gonad development] GO:0019901 [protein kinase binding] GO:0030513 [positive regulation of BMP signaling pathway] GO:0032911 [negative regulation of transforming growth factor beta1 production] GO:0032912 [negative regulation of transforming growth factor beta2 production] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045165 [cell fate commitment] GO:0045766 [positive regulation of angiogenesis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048468 [cell development] GO:0051145 [smooth muscle cell differentiation] GO:0060575 [intestinal epithelial cell differentiation] GO:0060947 [cardiac vascular smooth muscle cell differentiation] GO:0070848 [response to growth factor] GO:0071158 [positive regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia]