Expression of PELP1 in cancer - Summary

CANCER ATLAS

Gene description

Proline, glutamate and leucine rich protein 1

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA060760

GENE INFORMATION
Gene name	PELP1 (HGNC Symbol)
Synonyms	MNAR
Description	Proline, glutamate and leucine rich protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a transcription factor which coactivates transcription of estrogen receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the estrogen receptor family. This gene may be involved in the progression of several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	4669774 - 4704337
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141456 (version 83.38)
Entrez gene	27043
UniProt	Q8IZL8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IZL8
Antibodypedia	PELP1 antibodies

PROTEIN BROWSER

PELP1-001	PELP1-006	PELP1-008	PELP1-011	PELP1-015	PELP1-201	PELP1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PELP1-001 ENSP00000460300 ENST00000572293	C9JFV4 [Direct mapping] Proline-, glutamic acid- and leucine-rich protein 1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0071391 [cellular response to estrogen stimulus] Show all	1180 aa 124.9 kDa	No	0
PELP1-006 ENSP00000458985 ENST00000575101	I3L1P4 [Direct mapping] Proline-, glutamic acid- and leucine-rich protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		148 aa 15 kDa	No	0
PELP1-008 ENSP00000461419 ENST00000570387	I3L4P1 [Direct mapping] Proline-, glutamic acid- and leucine-rich protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0071391 [cellular response to estrogen stimulus] Show all	100 aa 11 kDa	No	0
PELP1-011 ENSP00000460959 ENST00000570571	I3L445 [Direct mapping] Proline-, glutamic acid- and leucine-rich protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	301 aa 32.1 kDa	No	0
PELP1-015 ENSP00000461625 ENST00000574876	Q8IZL8 [Direct mapping] Proline-, glutamic acid- and leucine-rich protein 1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003682 [chromatin binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0016020 [membrane] GO:0035327 [transcriptionally active chromatin] GO:0044822 [poly(A) RNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0071339 [MLL1 complex] GO:0071391 [cellular response to estrogen stimulus] Show all	1130 aa 119.7 kDa	No	0
PELP1-201 ENSP00000301396 ENST00000301396	C9JFV4 [Direct mapping] Proline-, glutamic acid- and leucine-rich protein 1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0071391 [cellular response to estrogen stimulus] Show all	1180 aa 124.9 kDa	No	0
PELP1-202 ENSP00000416231 ENST00000436683	E7EV54 [Direct mapping] Proline-, glutamic acid- and leucine-rich protein 1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] Show all	906 aa 96.9 kDa	No	0