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MINK1

GENERAL INFORMATION

Gene name

 MINK1

Gene description

 Misshapen-like kinase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA056296
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MINK1 (HGNC Symbol)

Synonyms

 B55, MAP4K6, MINK, YSK2, ZC3

Description

 Misshapen-like kinase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 4833388 - 4898061

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141503 (version 83.38)

Entrez gene

 50488

UniProt

 Q8N4C8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N4C8

Antibodypedia

 MINK1 antibodies

PROTEIN BROWSER
MINK1-001
MINK1-002
MINK1-003
MINK1-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MINK1-001
ENSP00000347427
ENST00000355280
Q8N4C8 [Direct mapping]
Misshapen-like kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001952 [regulation of cell-matrix adhesion]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007254 [JNK cascade]
GO:0007268 [synaptic transmission]
GO:0007275 [multicellular organismal development]
GO:0007346 [regulation of mitotic cell cycle]
GO:0014069 [postsynaptic density]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030054 [cell junction]
GO:0030334 [regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032147 [activation of protein kinase activity]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0045060 [negative thymic T cell selection]
GO:0045211 [postsynaptic membrane]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048812 [neuron projection morphogenesis]
GO:0048813 [dendrite morphogenesis]
GO:0070062 [extracellular exosome]
GO:2000311 [regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity]
Show all
 1332 aa
149.8 kDa 		No 0
MINK1-002
ENSP00000269296
ENST00000347992
Q8N4C8 [Direct mapping]
Misshapen-like kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001952 [regulation of cell-matrix adhesion]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007254 [JNK cascade]
GO:0007268 [synaptic transmission]
GO:0007275 [multicellular organismal development]
GO:0007346 [regulation of mitotic cell cycle]
GO:0014069 [postsynaptic density]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030054 [cell junction]
GO:0030334 [regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032147 [activation of protein kinase activity]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0045211 [postsynaptic membrane]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048812 [neuron projection morphogenesis]
GO:0048813 [dendrite morphogenesis]
GO:0070062 [extracellular exosome]
GO:2000311 [regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity]
Show all
 1303 aa
146.7 kDa 		No 0
MINK1-003
ENSP00000406487
ENST00000453408
Q8N4C8 [Direct mapping]
Misshapen-like kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001952 [regulation of cell-matrix adhesion]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007254 [JNK cascade]
GO:0007268 [synaptic transmission]
GO:0007275 [multicellular organismal development]
GO:0007346 [regulation of mitotic cell cycle]
GO:0014069 [postsynaptic density]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030054 [cell junction]
GO:0030334 [regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032147 [activation of protein kinase activity]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0045211 [postsynaptic membrane]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048812 [neuron projection morphogenesis]
GO:0048813 [dendrite morphogenesis]
GO:0070062 [extracellular exosome]
GO:2000311 [regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity]
Show all
 1312 aa
147.7 kDa 		No 0
MINK1-014
ENSP00000459102
ENST00000576037
I3L1U1 [Direct mapping]
Misshapen-like kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007346 [regulation of mitotic cell cycle]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0048812 [neuron projection morphogenesis]
Show all
 161 aa
18.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.