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ARHGDIA

CANCER ATLAS

Gene description

 Rho GDP dissociation inhibitor (GDI) alpha

Protein class

 Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021407
CAB010005

GENE INFORMATION

Gene name

 ARHGDIA (HGNC Symbol)

Synonyms

 GDIA1, RHOGDI

Description

 Rho GDP dissociation inhibitor (GDI) alpha (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 17

Cytoband

 q25.3

Chromosome location (bp)

 81867721 - 81871406

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141522 (version 83.38)

Entrez gene

 396

UniProt

 P52565 (UniProt - Evidence at protein level)

neXtProt

 NX_P52565

Antibodypedia

 ARHGDIA antibodies

PROTEIN BROWSER
ARHGDIA-001
ARHGDIA-002
ARHGDIA-006
ARHGDIA-009
ARHGDIA-012
ARHGDIA-013
ARHGDIA-015
ARHGDIA-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGDIA-001
ENSP00000269321
ENST00000269321
P52565 [Direct mapping]
Rho GDP-dissociation inhibitor 1
V9HWE8 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 47e; Rho GDP dissociation inhibitor (GDI) alpha, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005094 [Rho GDP-dissociation inhibitor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006928 [movement of cell or subcellular component]
GO:0007162 [negative regulation of cell adhesion]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0043066 [negative regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050770 [regulation of axonogenesis]
GO:0050771 [negative regulation of axonogenesis]
GO:0050772 [positive regulation of axonogenesis]
GO:0050790 [regulation of catalytic activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0071526 [semaphorin-plexin signaling pathway]
Show all
 204 aa
23.2 kDa 		No 0
ARHGDIA-002
ENSP00000383556
ENST00000400721
P52565 [Direct mapping]
Rho GDP-dissociation inhibitor 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005094 [Rho GDP-dissociation inhibitor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006928 [movement of cell or subcellular component]
GO:0007162 [negative regulation of cell adhesion]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0043066 [negative regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050770 [regulation of axonogenesis]
GO:0050771 [negative regulation of axonogenesis]
GO:0050772 [positive regulation of axonogenesis]
GO:0050790 [regulation of catalytic activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0071526 [semaphorin-plexin signaling pathway]
Show all
 160 aa
18.2 kDa 		No 0
ARHGDIA-006
ENSP00000462209
ENST00000583868
J3KRY1 [Direct mapping]
Rho GDP-dissociation inhibitor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005094 [Rho GDP-dissociation inhibitor activity]
GO:0005737 [cytoplasm]
GO:0050790 [regulation of catalytic activity]
Show all
 249 aa
27.1 kDa 		No 0
ARHGDIA-009
ENSP00000463939
ENST00000584461
J3QQX2 [Direct mapping]
Rho GDP-dissociation inhibitor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001772 [immunological synapse]
GO:0005094 [Rho GDP-dissociation inhibitor activity]
GO:0005504 [fatty acid binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0016020 [membrane]
GO:0017048 [Rho GTPase binding]
GO:0019901 [protein kinase binding]
GO:0030336 [negative regulation of cell migration]
GO:0032880 [regulation of protein localization]
GO:0050790 [regulation of catalytic activity]
GO:0051879 [Hsp90 protein binding]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071461 [cellular response to redox state]
GO:0071526 [semaphorin-plexin signaling pathway]
Show all
 235 aa
25.8 kDa 		No 0
ARHGDIA-012
ENSP00000441348
ENST00000541078
P52565 [Direct mapping]
Rho GDP-dissociation inhibitor 1
V9HWE8 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 47e; Rho GDP dissociation inhibitor (GDI) alpha, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005094 [Rho GDP-dissociation inhibitor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006928 [movement of cell or subcellular component]
GO:0007162 [negative regulation of cell adhesion]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0043066 [negative regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050770 [regulation of axonogenesis]
GO:0050771 [negative regulation of axonogenesis]
GO:0050772 [positive regulation of axonogenesis]
GO:0050790 [regulation of catalytic activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0071526 [semaphorin-plexin signaling pathway]
Show all
 204 aa
23.2 kDa 		No 0
ARHGDIA-013
ENSP00000462960
ENST00000579121
J3KTF8 [Direct mapping]
Rho GDP-dissociation inhibitor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005094 [Rho GDP-dissociation inhibitor activity]
GO:0005737 [cytoplasm]
GO:0050790 [regulation of catalytic activity]
Show all
 194 aa
21.6 kDa 		No 0
ARHGDIA-015
ENSP00000464205
ENST00000580685
P52565 [Direct mapping]
Rho GDP-dissociation inhibitor 1
V9HWE8 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 47e; Rho GDP dissociation inhibitor (GDI) alpha, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005094 [Rho GDP-dissociation inhibitor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006928 [movement of cell or subcellular component]
GO:0007162 [negative regulation of cell adhesion]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0043066 [negative regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050770 [regulation of axonogenesis]
GO:0050771 [negative regulation of axonogenesis]
GO:0050772 [positive regulation of axonogenesis]
GO:0050790 [regulation of catalytic activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0071526 [semaphorin-plexin signaling pathway]
Show all
 204 aa
23.2 kDa 		No 0
ARHGDIA-016
ENSP00000461956
ENST00000581876
J3KRE2 [Direct mapping]
Rho GDP-dissociation inhibitor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005094 [Rho GDP-dissociation inhibitor activity]
GO:0005737 [cytoplasm]
GO:0050790 [regulation of catalytic activity]
Show all
 129 aa
14.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.