Expression of SLC16A3 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 16 (monocarboxylate transporter), member 3

Protein class

Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA021451	CAB017490

GENE INFORMATION
Gene name	SLC16A3 (HGNC Symbol)
Synonyms	MCT3, MCT4
Description	Solute carrier family 16 (monocarboxylate transporter), member 3 (HGNC Symbol)
Entrez gene summary	Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	82228397 - 82261129
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141526 (version 83.38)
Entrez gene	9123
UniProt	O15427 (UniProt - Evidence at protein level)
neXtProt	NX_O15427
Antibodypedia	SLC16A3 antibodies

PROTEIN BROWSER

SLC16A3-001	SLC16A3-002	SLC16A3-004	SLC16A3-005	SLC16A3-007	SLC16A3-008	SLC16A3-009	SLC16A3-010	SLC16A3-012	SLC16A3-015	SLC16A3-016	SLC16A3-018	SLC16A3-201	SLC16A3-202	SLC16A3-203	SLC16A3-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC16A3-001 ENSP00000463978 ENST00000581287	O15427 [Direct mapping] Monocarboxylate transporter 4 A0A024R8U1 [Target identity:100%; Query identity:100%] Solute carrier family 16 (Monocarboxylic acid transporters), member 3, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006090 [pyruvate metabolic process] GO:0007596 [blood coagulation] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015129 [lactate transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015629 [actin cytoskeleton] GO:0015718 [monocarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0035879 [plasma membrane lactate transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0050900 [leukocyte migration] GO:0055085 [transmembrane transport] Show all	465 aa 49.5 kDa	No	>9
SLC16A3-002 ENSP00000462405 ENST00000582743	O15427 [Direct mapping] Monocarboxylate transporter 4 A0A024R8U1 [Target identity:100%; Query identity:100%] Solute carrier family 16 (Monocarboxylic acid transporters), member 3, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006090 [pyruvate metabolic process] GO:0007596 [blood coagulation] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015129 [lactate transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015629 [actin cytoskeleton] GO:0015718 [monocarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0035879 [plasma membrane lactate transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0050900 [leukocyte migration] GO:0055085 [transmembrane transport] Show all	465 aa 49.5 kDa	No	>9
SLC16A3-004 ENSP00000464625 ENST00000584689	J3QSC3 [Direct mapping] Monocarboxylate transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0015129 [lactate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] Show all	291 aa 30.8 kDa	No	8
SLC16A3-005 ENSP00000462854 ENST00000583237	J3KT83 [Direct mapping] Monocarboxylate transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0015129 [lactate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] Show all	219 aa 23.2 kDa	No	6
SLC16A3-007 ENSP00000463880 ENST00000580098	J3QQS9 [Direct mapping] Monocarboxylate transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0015129 [lactate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] Show all	235 aa 25 kDa	No	6
SLC16A3-008 ENSP00000463508 ENST00000578522	J3QLE3 [Direct mapping] Monocarboxylate transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0015129 [lactate transmembrane transporter activity] GO:0035879 [plasma membrane lactate transport] Show all	135 aa 14.2 kDa	No	4
SLC16A3-009 ENSP00000464112 ENST00000580189	J3QRA0 [Direct mapping] Monocarboxylate transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0015129 [lactate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] Show all	223 aa 23.6 kDa	No	6
SLC16A3-010 ENSP00000464381 ENST00000582946	J3QRU2 [Direct mapping] Monocarboxylate transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0015129 [lactate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] Show all	163 aa 17.2 kDa	No	5
SLC16A3-012 ENSP00000463912 ENST00000578684	J3QQV2 [Direct mapping] Monocarboxylate transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0015129 [lactate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] Show all	264 aa 28.1 kDa	No	7
SLC16A3-015 ENSP00000464326 ENST00000582715	J3QRP8 [Direct mapping] Monocarboxylate transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0015129 [lactate transmembrane transporter activity] GO:0035879 [plasma membrane lactate transport] Show all	80 aa 8.4 kDa	No	1
SLC16A3-016 ENSP00000463063 ENST00000577650	J3KTM6 [Direct mapping] Monocarboxylate transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0015129 [lactate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] Show all	157 aa 16.7 kDa	No	4
SLC16A3-018 ENSP00000463005 ENST00000583025	J3KTI8 [Direct mapping] Monocarboxylate transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0015129 [lactate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] Show all	306 aa 32.3 kDa	No	6
SLC16A3-201 ENSP00000376150 ENST00000392339	O15427 [Direct mapping] Monocarboxylate transporter 4 A0A024R8U1 [Target identity:100%; Query identity:100%] Solute carrier family 16 (Monocarboxylic acid transporters), member 3, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006090 [pyruvate metabolic process] GO:0007596 [blood coagulation] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015129 [lactate transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015629 [actin cytoskeleton] GO:0015718 [monocarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0035879 [plasma membrane lactate transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0050900 [leukocyte migration] GO:0055085 [transmembrane transport] Show all	465 aa 49.5 kDa	No	>9
SLC16A3-202 ENSP00000376152 ENST00000392341	O15427 [Direct mapping] Monocarboxylate transporter 4 A0A024R8U1 [Target identity:100%; Query identity:100%] Solute carrier family 16 (Monocarboxylic acid transporters), member 3, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006090 [pyruvate metabolic process] GO:0007596 [blood coagulation] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015129 [lactate transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015629 [actin cytoskeleton] GO:0015718 [monocarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0035879 [plasma membrane lactate transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0050900 [leukocyte migration] GO:0055085 [transmembrane transport] Show all	465 aa 49.5 kDa	No	>9
SLC16A3-203 ENSP00000483212 ENST00000617373	O15427 [Direct mapping] Monocarboxylate transporter 4 A0A024R8U1 [Target identity:100%; Query identity:100%] Solute carrier family 16 (Monocarboxylic acid transporters), member 3, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006090 [pyruvate metabolic process] GO:0007596 [blood coagulation] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015129 [lactate transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015629 [actin cytoskeleton] GO:0015718 [monocarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0035879 [plasma membrane lactate transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0050900 [leukocyte migration] GO:0055085 [transmembrane transport] Show all	465 aa 49.5 kDa	No	>9
SLC16A3-204 ENSP00000482013 ENST00000619321	O15427 [Direct mapping] Monocarboxylate transporter 4 A0A024R8U1 [Target identity:100%; Query identity:100%] Solute carrier family 16 (Monocarboxylic acid transporters), member 3, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006090 [pyruvate metabolic process] GO:0007596 [blood coagulation] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015129 [lactate transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015629 [actin cytoskeleton] GO:0015718 [monocarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0035879 [plasma membrane lactate transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0050900 [leukocyte migration] GO:0055085 [transmembrane transport] Show all	465 aa 49.5 kDa	No	>9