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RPTOR

CANCER ATLAS

Gene description

 Regulatory associated protein of MTOR, complex 1

Protein class

 Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB013514

GENE INFORMATION

Gene name

 RPTOR (HGNC Symbol)

Synonyms

 KIAA1303, KOG1, Mip1, raptor

Description

 Regulatory associated protein of MTOR, complex 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

 17

Cytoband

 q25.3

Chromosome location (bp)

 80544819 - 80966371

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141564 (version 83.38)

Entrez gene

 57521

UniProt

 Q8N122 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N122

Antibodypedia

 RPTOR antibodies

PROTEIN BROWSER
RPTOR-001
RPTOR-005
RPTOR-006
RPTOR-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPTOR-001
ENSP00000307272
ENST00000306801
Q8N122 [Direct mapping]
Regulatory-associated protein of mTOR
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001030 [RNA polymerase III type 1 promoter DNA binding]
GO:0001031 [RNA polymerase III type 2 promoter DNA binding]
GO:0001032 [RNA polymerase III type 3 promoter DNA binding]
GO:0001156 [TFIIIC-class transcription factor binding]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007050 [cell cycle arrest]
GO:0008286 [insulin receptor signaling pathway]
GO:0008361 [regulation of cell size]
GO:0010467 [gene expression]
GO:0016049 [cell growth]
GO:0016236 [macroautophagy]
GO:0019901 [protein kinase binding]
GO:0030425 [dendrite]
GO:0031669 [cellular response to nutrient levels]
GO:0031929 [TOR signaling]
GO:0031931 [TORC1 complex]
GO:0032008 [positive regulation of TOR signaling]
GO:0032403 [protein complex binding]
GO:0034605 [cellular response to heat]
GO:0042325 [regulation of phosphorylation]
GO:0043025 [neuronal cell body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045945 [positive regulation of transcription from RNA polymerase III promoter]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071889 [14-3-3 protein binding]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:1900034 [regulation of cellular response to heat]
Show all
 1335 aa
149 kDa 		No 1
RPTOR-005
ENSP00000460136
ENST00000570891
Q8N122 [Direct mapping]
Regulatory-associated protein of mTOR
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001030 [RNA polymerase III type 1 promoter DNA binding]
GO:0001031 [RNA polymerase III type 2 promoter DNA binding]
GO:0001032 [RNA polymerase III type 3 promoter DNA binding]
GO:0001156 [TFIIIC-class transcription factor binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007050 [cell cycle arrest]
GO:0008286 [insulin receptor signaling pathway]
GO:0008361 [regulation of cell size]
GO:0010467 [gene expression]
GO:0016049 [cell growth]
GO:0016236 [macroautophagy]
GO:0019901 [protein kinase binding]
GO:0031669 [cellular response to nutrient levels]
GO:0031929 [TOR signaling]
GO:0031931 [TORC1 complex]
GO:0032008 [positive regulation of TOR signaling]
GO:0032403 [protein complex binding]
GO:0034605 [cellular response to heat]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045945 [positive regulation of transcription from RNA polymerase III promoter]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071889 [14-3-3 protein binding]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:1900034 [regulation of cellular response to heat]
Show all
 379 aa
43.3 kDa 		No 0
RPTOR-006
ENSP00000442479
ENST00000544334
Q8N122 [Direct mapping]
Regulatory-associated protein of mTOR
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001030 [RNA polymerase III type 1 promoter DNA binding]
GO:0001031 [RNA polymerase III type 2 promoter DNA binding]
GO:0001032 [RNA polymerase III type 3 promoter DNA binding]
GO:0001156 [TFIIIC-class transcription factor binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007050 [cell cycle arrest]
GO:0008286 [insulin receptor signaling pathway]
GO:0008361 [regulation of cell size]
GO:0010467 [gene expression]
GO:0016049 [cell growth]
GO:0016236 [macroautophagy]
GO:0019901 [protein kinase binding]
GO:0031669 [cellular response to nutrient levels]
GO:0031929 [TOR signaling]
GO:0031931 [TORC1 complex]
GO:0032008 [positive regulation of TOR signaling]
GO:0032403 [protein complex binding]
GO:0034605 [cellular response to heat]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045945 [positive regulation of transcription from RNA polymerase III promoter]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071889 [14-3-3 protein binding]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:1900034 [regulation of cellular response to heat]
Show all
 1177 aa
131.5 kDa 		No 1
RPTOR-011
ENSP00000460940
ENST00000576366
I3L436 [Direct mapping]
Regulatory-associated protein of mTOR
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 235 aa
24.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.