Tissue expression of DYM - Summary - The Human Protein Atlas

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DYM

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	DYM
Gene description	Dymeclin
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General granular cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA043551
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DYM (HGNC Symbol)
Synonyms	DMC, FLJ20071, SMC
Description	Dymeclin (HGNC Symbol)
Entrez gene summary	This gene encodes a protein which is necessary for normal skeletal development and brain function. Mutations in this gene are associated with two types of recessive osteochondrodysplasia, Dyggve-Melchior-Clausen (DMC) dysplasia and Smith-McCort (SMC) dysplasia, which involve both skeletal defects and mental retardation. [provided by RefSeq, Jul 2008]
Chromosome	18
Cytoband	q21.1
Chromosome location (bp)	49041474 - 49461347
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141627 (version 83.38)
Entrez gene	54808
UniProt	Q7RTS9 (UniProt - Evidence at protein level)
neXtProt	NX_Q7RTS9
Antibodypedia	DYM antibodies

PROTEIN BROWSER

DYM-001	DYM-002	DYM-003	DYM-006	DYM-007	DYM-008	DYM-009	DYM-010	DYM-012	DYM-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DYM-001 ENSP00000269445 ENST00000269445	Q7RTS9 [Direct mapping] Dymeclin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0007030 [Golgi organization] GO:0019899 [enzyme binding] GO:0060348 [bone development] Show all	669 aa 75.9 kDa	No	1
DYM-002 ENSP00000395942 ENST00000442713	Q7RTS9 [Direct mapping] Dymeclin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0007030 [Golgi organization] GO:0019899 [enzyme binding] GO:0060348 [bone development] Show all	479 aa 54.4 kDa	No	1
DYM-003 ENSP00000462657 ENST00000582399	J3KSU8 [Direct mapping] Dymeclin Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		122 aa 14 kDa	No	0
DYM-006 ENSP00000464089 ENST00000583353	J3QR81 [Direct mapping] Dymeclin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		109 aa 12.2 kDa	No	0
DYM-007 ENSP00000464183 ENST00000581738	J3QRF2 [Direct mapping] Dymeclin Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		142 aa 15.3 kDa	No	0
DYM-008 ENSP00000462466 ENST00000583280	J3KSF9 [Direct mapping] Dymeclin Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		139 aa 15 kDa	No	0
DYM-009 ENSP00000464653 ENST00000583225	J3QSE7 [Direct mapping] Dymeclin Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		141 aa 15.3 kDa	No	0
DYM-010 ENSP00000461989 ENST00000584983	J3KRG4 [Direct mapping] Dymeclin Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		163 aa 17.7 kDa	No	0
DYM-012 ENSP00000463892 ENST00000578396	J3QQT7 [Direct mapping] Dymeclin Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		116 aa 13 kDa	No	0
DYM-018 ENSP00000464163 ENST00000577734	J3QRD8 [Direct mapping] Dymeclin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		67 aa 7.3 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.