We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Insulin-like growth factor binding protein 4 (HGNC Symbol)
Entrez gene summary
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development] GO:0001558 [regulation of cell growth] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006259 [DNA metabolic process] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0008283 [cell proliferation] GO:0010906 [regulation of glucose metabolic process] GO:0031994 [insulin-like growth factor I binding] GO:0031995 [insulin-like growth factor II binding] GO:0040008 [regulation of growth] GO:0043410 [positive regulation of MAPK cascade] GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway] GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway] GO:0044267 [cellular protein metabolic process] GO:0044342 [type B pancreatic cell proliferation]
