Expression of FKBP10 in cancer - Summary

CANCER ATLAS

Gene description

FK506 binding protein 10, 65 kDa

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA051171	HPA057021

GENE INFORMATION
Gene name	FKBP10 (HGNC Symbol)
Synonyms	FKBP6, FLJ20683, FLJ22041, FLJ23833, hFKBP65
Description	FK506 binding protein 10, 65 kDa (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	41812680 - 41823217
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141756 (version 83.38)
Entrez gene	60681
UniProt	Q96AY3 (UniProt - Evidence at protein level)
neXtProt	NX_Q96AY3
Antibodypedia	FKBP10 antibodies

PROTEIN BROWSER

FKBP10-001	FKBP10-003	FKBP10-004	FKBP10-010	FKBP10-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FKBP10-001 ENSP00000317232 ENST00000321562	Q96AY3 [Direct mapping] Peptidyl-prolyl cis-trans isomerase FKBP10 A0A024R1W3 [Target identity:100%; Query identity:100%] FK506 binding protein 10, 65 kDa, isoform CRA_a Show all	Enzymes ENZYME proteins Isomerase MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0061077 [chaperone-mediated protein folding] Show all	582 aa 64.2 kDa	Yes	0
FKBP10-003 ENSP00000408232 ENST00000429461	C9JPC3 [Direct mapping] Peptidyl-prolyl cis-trans isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0061077 [chaperone-mediated protein folding] Show all	81 aa 8.9 kDa	No	0
FKBP10-004 ENSP00000416822 ENST00000455106	H0Y827 [Direct mapping] Peptidyl-prolyl cis-trans isomerase FKBP10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005509 [calcium ion binding] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0061077 [chaperone-mediated protein folding] Show all	386 aa 42.2 kDa	No	0
FKBP10-010 ENSP00000468703 ENST00000585664	K7ESG6 [Direct mapping] Peptidyl-prolyl cis-trans isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0061077 [chaperone-mediated protein folding] Show all	172 aa 19.2 kDa	No	0
FKBP10-011 ENSP00000466097 ENST00000585922	K7ELI6 [Direct mapping] Peptidyl-prolyl cis-trans isomerase Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0061077 [chaperone-mediated protein folding] Show all	171 aa 18.9 kDa	Yes	0