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BRD4

CANCER ATLAS

Gene description

 Bromodomain containing 4

Protein class

 Cancer-related genes, Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY
HPA015055
HPA061646
CAB068177
CAB068178

GENE INFORMATION

Gene name

 BRD4 (HGNC Symbol)

Synonyms

 CAP, HUNK1, HUNKI, MCAP

Description

 Bromodomain containing 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.12

Chromosome location (bp)

 15235519 - 15332545

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141867 (version 83.38)

Entrez gene

 23476

UniProt

 O60885 (UniProt - Evidence at protein level)

neXtProt

 NX_O60885

Antibodypedia

 BRD4 antibodies

PROTEIN BROWSER
BRD4-001
BRD4-002
BRD4-003
BRD4-004
BRD4-008
BRD4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BRD4-001
ENSP00000263377
ENST00000263377
O60885 [Direct mapping]
Bromodomain-containing protein 4
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000790 [nuclear chromatin]
GO:0000794 [condensed nuclear chromosome]
GO:0001833 [inner cell mass cell proliferation]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007059 [chromosome segregation]
GO:0008024 [positive transcription elongation factor complex b]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0016032 [viral process]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043388 [positive regulation of DNA binding]
GO:0043983 [histone H4-K12 acetylation]
GO:0044154 [histone H3-K14 acetylation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050727 [regulation of inflammatory response]
GO:0070577 [lysine-acetylated histone binding]
GO:1901407 [regulation of phosphorylation of RNA polymerase II C-terminal domain]
GO:2000002 [negative regulation of DNA damage checkpoint]
Show all
 1362 aa
152.2 kDa 		No 0
BRD4-002
ENSP00000360901
ENST00000371835
O60885 [Direct mapping]
Bromodomain-containing protein 4
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000794 [condensed nuclear chromosome]
GO:0002039 [p53 binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0016032 [viral process]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050727 [regulation of inflammatory response]
GO:0070577 [lysine-acetylated histone binding]
GO:1901407 [regulation of phosphorylation of RNA polymerase II C-terminal domain]
GO:2000002 [negative regulation of DNA damage checkpoint]
Show all
 722 aa
80.5 kDa 		No 0
BRD4-003
ENSP00000353112
ENST00000360016
O60885 [Direct mapping]
Bromodomain-containing protein 4
A0A024R7H8 [Target identity:100%; Query identity:100%]
Bromodomain containing 4, isoform CRA_b
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000794 [condensed nuclear chromosome]
GO:0002039 [p53 binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0016032 [viral process]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050727 [regulation of inflammatory response]
GO:0070577 [lysine-acetylated histone binding]
GO:1901407 [regulation of phosphorylation of RNA polymerase II C-terminal domain]
GO:2000002 [negative regulation of DNA damage checkpoint]
Show all
 794 aa
88.3 kDa 		No 0
BRD4-004
ENSP00000470481
ENST00000594841
M0QZD9 [Direct mapping]
Bromodomain-containing protein 4
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 572 aa
63.8 kDa 		No 0
BRD4-008
ENSP00000471240
ENST00000601941
M0R0H4 [Direct mapping]
Bromodomain-containing protein 4
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 105 aa
11.7 kDa 		No 0
BRD4-201
ENSP00000486621
ENST00000630599
M0QYW0 [Direct mapping]
Bromodomain containing 4, isoform CRA_c; Bromodomain-containing protein 4
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 146 aa
16.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.