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VAV1

CANCER ATLAS

Gene description

 Vav 1 guanine nucleotide exchange factor

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001864

GENE INFORMATION

Gene name

 VAV1 (HGNC Symbol)

Synonyms

 VAV

Description

 Vav 1 guanine nucleotide exchange factor (HGNC Symbol)

Entrez gene summary

 This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 6772714 - 6857366

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141968 (version 83.38)

Entrez gene

 7409

UniProt

 P15498 (UniProt - Evidence at protein level)

neXtProt

 NX_P15498

Antibodypedia

 VAV1 antibodies

PROTEIN BROWSER
VAV1-001
VAV1-002
VAV1-003
VAV1-004
VAV1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VAV1-001
ENSP00000472929
ENST00000602142
P15498 [Direct mapping]
Proto-oncogene vav
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006909 [phagocytosis]
GO:0006955 [immune response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0008361 [regulation of cell size]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0030168 [platelet activation]
GO:0030593 [neutrophil chemotaxis]
GO:0030676 [Rac guanyl-nucleotide exchange factor activity]
GO:0031295 [T cell costimulation]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042110 [T cell activation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0045785 [positive regulation of cell adhesion]
GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0072593 [reactive oxygen species metabolic process]
GO:0097190 [apoptotic signaling pathway]
Show all
 845 aa
98.3 kDa 		No 0
VAV1-002
ENSP00000302269
ENST00000304076
A0A0A0MR07 [Direct mapping]
Proto-oncogene vav
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
Show all
 823 aa
95.8 kDa 		No 0
VAV1-003
ENSP00000469450
ENST00000596764
P15498 [Direct mapping]
Proto-oncogene vav
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0008361 [regulation of cell size]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0030168 [platelet activation]
GO:0031295 [T cell costimulation]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 813 aa
94.5 kDa 		No 0
VAV1-004
ENSP00000472803
ENST00000599806
Q96D37 [Direct mapping]
Proto-oncogene vav; VAV1 protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
Show all
 790 aa
92 kDa 		No 0
VAV1-201
ENSP00000443242
ENST00000539284
F5H5P4 [Direct mapping]
Proto-oncogene vav
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
Show all
 789 aa
91.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.