Expression of IFITM3 in cancer - Summary

CANCER ATLAS

Gene description

Interferon induced transmembrane protein 3

Protein class

Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA004337

GENE INFORMATION
Gene name	IFITM3 (HGNC Symbol)
Synonyms	1-8U
Description	Interferon induced transmembrane protein 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012]
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	319669 - 327537
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142089 (version 83.38)
Entrez gene	10410
UniProt	Q01628 (UniProt - Evidence at protein level)
neXtProt	NX_Q01628
Antibodypedia	IFITM3 antibodies

PROTEIN BROWSER

IFITM3-001	IFITM3-002	IFITM3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IFITM3-001 ENSP00000382707 ENST00000399808	Q01628 [Direct mapping] Interferon-induced transmembrane protein 3 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0009607 [response to biotic stimulus] GO:0009615 [response to virus] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0031902 [late endosome membrane] GO:0032897 [negative regulation of viral transcription] GO:0034341 [response to interferon-gamma] GO:0035455 [response to interferon-alpha] GO:0035456 [response to interferon-beta] GO:0045071 [negative regulation of viral genome replication] GO:0046597 [negative regulation of viral entry into host cell] GO:0051607 [defense response to virus] GO:0060337 [type I interferon signaling pathway] GO:0070062 [extracellular exosome] Show all	133 aa 14.6 kDa	No	2
IFITM3-002 ENSP00000432108 ENST00000526811	E9PS44 [Direct mapping] Interferon-induced transmembrane protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0009607 [response to biotic stimulus] GO:0016021 [integral component of membrane] Show all	112 aa 12.3 kDa	No	2
IFITM3-004 ENSP00000473544 ENST00000602735	E9PS44 [Direct mapping] Interferon-induced transmembrane protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0009607 [response to biotic stimulus] GO:0016021 [integral component of membrane] Show all	112 aa 12.3 kDa	No	2