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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.
RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, kidney, lymph node)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
GENE INFORMATION
Gene name
DNMT3L (HGNC Symbol)
Synonyms
MGC1090
Description
DNA (cytosine-5-)-methyltransferase 3-like (HGNC Symbol)
Entrez gene summary
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]