Tissue expression of DNMT3L - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DNMT3L
Gene description	DNA (cytosine-5-)-methyltransferase 3-like
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (liver, kidney, lymph node)
GTEx:	Group enriched (liver, kidney)
FANTOM5:	Not detected

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA066780
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (liver, kidney, lymph node)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (liver, kidney)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Not detected

GENE INFORMATION
Gene name	DNMT3L (HGNC Symbol)
Synonyms	MGC1090
Description	DNA (cytosine-5-)-methyltransferase 3-like (HGNC Symbol)
Entrez gene summary	CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Chromosome	21
Cytoband	q22.3
Chromosome location (bp)	44246339 - 44262216
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142182 (version 83.38)
Entrez gene	29947
UniProt	Q9UJW3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UJW3
Antibodypedia	DNMT3L antibodies

PROTEIN BROWSER

DNMT3L-001	DNMT3L-002	DNMT3L-003	DNMT3L-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNMT3L-001 ENSP00000270172 ENST00000270172	Q9UJW3 [Direct mapping] DNA (cytosine-5)-methyltransferase 3-like Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006306 [DNA methylation] GO:0006349 [regulation of gene expression by genetic imprinting] GO:0007283 [spermatogenesis] GO:0008047 [enzyme activator activity] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0032776 [DNA methylation on cytosine] GO:0040029 [regulation of gene expression, epigenetic] GO:0043085 [positive regulation of catalytic activity] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	387 aa 43.7 kDa	No	0
DNMT3L-002 ENSP00000400242 ENST00000431166	C9J0T5 [Direct mapping] DNA (cytosine-5)-methyltransferase 3-like Show all	Predicted intracellular proteins Show all		288 aa 32.4 kDa	No	0
DNMT3L-003 ENSP00000411608 ENST00000436357	H7C3F7 [Direct mapping] DNA (cytosine-5)-methyltransferase 3-like Show all	Predicted intracellular proteins Show all		181 aa 20.4 kDa	No	0
DNMT3L-004 ENSP00000486001 ENST00000628202	Q9UJW3 [Direct mapping] DNA (cytosine-5)-methyltransferase 3-like Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006306 [DNA methylation] GO:0006349 [regulation of gene expression by genetic imprinting] GO:0007283 [spermatogenesis] GO:0008047 [enzyme activator activity] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0032776 [DNA methylation on cytosine] GO:0040029 [regulation of gene expression, epigenetic] GO:0043085 [positive regulation of catalytic activity] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	386 aa 43.6 kDa	No	0