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TRPM2

CANCER ATLAS

Gene description

 Transient receptor potential cation channel, subfamily M, member 2

Protein class

 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035260

GENE INFORMATION

Gene name

 TRPM2 (HGNC Symbol)

Synonyms

 EREG1, KNP3, LTRPC2, NUDT9H, NUDT9L1, TRPC7

Description

 Transient receptor potential cation channel, subfamily M, member 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 44350163 - 44443081

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142185 (version 83.38)

Entrez gene

 7226

UniProt

 O94759 (UniProt - Evidence at protein level)

neXtProt

 NX_O94759

Antibodypedia

 TRPM2 antibodies

PROTEIN BROWSER
TRPM2-001
TRPM2-002
TRPM2-004
TRPM2-006
TRPM2-007
TRPM2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRPM2-001
ENSP00000381023
ENST00000397928
O94759 [Direct mapping]
Transient receptor potential cation channel subfamily M member 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005272 [sodium channel activity]
GO:0005384 [manganese ion transmembrane transporter activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0032024 [positive regulation of insulin secretion]
GO:0033194 [response to hydroperoxide]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0044849 [estrous cycle]
GO:0047631 [ADP-ribose diphosphatase activity]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0071421 [manganese ion transmembrane transport]
GO:0098703 [calcium ion import across plasma membrane]
GO:1903223 [positive regulation of oxidative stress-induced neuron death]
Show all
 1503 aa
171.2 kDa 		No 7
TRPM2-002
ENSP00000300481
ENST00000300481
O94759 [Direct mapping]
Transient receptor potential cation channel subfamily M member 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
Show all
GO:0005216 [ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005272 [sodium channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0047631 [ADP-ribose diphosphatase activity]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
Show all
 1449 aa
165.3 kDa 		No 7
TRPM2-004
ENSP00000300482
ENST00000300482
O94759 [Direct mapping]
Transient receptor potential cation channel subfamily M member 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
Show all
GO:0005216 [ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005272 [sodium channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0047631 [ADP-ribose diphosphatase activity]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
Show all
 1503 aa
171.2 kDa 		No 7
TRPM2-006
ENSP00000393982
ENST00000431901
C9JZQ8 [Direct mapping]
Transient receptor potential cation channel subfamily M member 2
Show all
Predicted intracellular proteins
Show all
GO:0005261 [cation channel activity]
GO:0006979 [response to oxidative stress]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0047631 [ADP-ribose diphosphatase activity]
GO:0098655 [cation transmembrane transport]
Show all
 144 aa
16.4 kDa 		No 0
TRPM2-007
ENSP00000381026
ENST00000397932
E9PGK7 [Direct mapping]
Transient receptor potential cation channel subfamily M member 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005261 [cation channel activity]
GO:0006811 [ion transport]
GO:0006979 [response to oxidative stress]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016787 [hydrolase activity]
GO:0047631 [ADP-ribose diphosphatase activity]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
 1553 aa
176.5 kDa 		No 7
TRPM2-201
ENSP00000477514
ENST00000621064
A0A087WT16 [Direct mapping]
Transient receptor potential cation channel subfamily M member 2
Show all
Predicted intracellular proteins
Show all
GO:0005261 [cation channel activity]
GO:0006979 [response to oxidative stress]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016787 [hydrolase activity]
GO:0047631 [ADP-ribose diphosphatase activity]
GO:0098655 [cation transmembrane transport]
Show all
 247 aa
28.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.