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The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000060 [protein import into nucleus, translocation] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005979 [regulation of glycogen biosynthetic process] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006417 [regulation of translation] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0006469 [negative regulation of protein kinase activity] GO:0006809 [nitric oxide biosynthetic process] GO:0006915 [apoptotic process] GO:0006924 [activation-induced cell death of T cells] GO:0006979 [response to oxidative stress] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007596 [blood coagulation] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009408 [response to heat] GO:0010467 [gene expression] GO:0010507 [negative regulation of autophagy] GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] GO:0010907 [positive regulation of glucose metabolic process] GO:0010951 [negative regulation of endopeptidase activity] GO:0010975 [regulation of neuron projection development] GO:0012501 [programmed cell death] GO:0015630 [microtubule cytoskeleton] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019899 [enzyme binding] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030307 [positive regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0031018 [endocrine pancreas development] GO:0031295 [T cell costimulation] GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] GO:0031982 [vesicle] GO:0031999 [negative regulation of fatty acid beta-oxidation] GO:0032079 [positive regulation of endodeoxyribonuclease activity] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032869 [cellular response to insulin stimulus] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034405 [response to fluid shear stress] GO:0035556 [intracellular signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding] GO:0043488 [regulation of mRNA stability] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045861 [negative regulation of proteolysis] GO:0046209 [nitric oxide metabolic process] GO:0046326 [positive regulation of glucose import] GO:0046777 [protein autophosphorylation] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060416 [response to growth hormone] GO:0060644 [mammary gland epithelial cell differentiation] GO:0061024 [membrane organization] GO:0070141 [response to UV-A] GO:0071889 [14-3-3 protein binding] GO:0072655 [establishment of protein localization to mitochondrion] GO:0072656 [maintenance of protein location in mitochondrion] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900182 [positive regulation of protein localization to nucleus] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901215 [negative regulation of neuron death] GO:1901976 [regulation of cell cycle checkpoint] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903599 [positive regulation of mitophagy] GO:1990090 [cellular response to nerve growth factor stimulus] GO:1990418 [response to insulin-like growth factor stimulus] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000060 [protein import into nucleus, translocation] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005979 [regulation of glycogen biosynthetic process] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006417 [regulation of translation] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0006469 [negative regulation of protein kinase activity] GO:0006809 [nitric oxide biosynthetic process] GO:0006915 [apoptotic process] GO:0006924 [activation-induced cell death of T cells] GO:0006979 [response to oxidative stress] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007596 [blood coagulation] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009408 [response to heat] GO:0010467 [gene expression] GO:0010507 [negative regulation of autophagy] GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] GO:0010907 [positive regulation of glucose metabolic process] GO:0010951 [negative regulation of endopeptidase activity] GO:0010975 [regulation of neuron projection development] GO:0012501 [programmed cell death] GO:0015630 [microtubule cytoskeleton] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019899 [enzyme binding] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030307 [positive regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0031018 [endocrine pancreas development] GO:0031295 [T cell costimulation] GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] GO:0031982 [vesicle] GO:0031999 [negative regulation of fatty acid beta-oxidation] GO:0032079 [positive regulation of endodeoxyribonuclease activity] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032869 [cellular response to insulin stimulus] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034405 [response to fluid shear stress] GO:0035556 [intracellular signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding] GO:0043488 [regulation of mRNA stability] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045861 [negative regulation of proteolysis] GO:0046209 [nitric oxide metabolic process] GO:0046326 [positive regulation of glucose import] GO:0046777 [protein autophosphorylation] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060416 [response to growth hormone] GO:0060644 [mammary gland epithelial cell differentiation] GO:0061024 [membrane organization] GO:0070141 [response to UV-A] GO:0071889 [14-3-3 protein binding] GO:0072655 [establishment of protein localization to mitochondrion] GO:0072656 [maintenance of protein location in mitochondrion] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900182 [positive regulation of protein localization to nucleus] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901215 [negative regulation of neuron death] GO:1901976 [regulation of cell cycle checkpoint] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903599 [positive regulation of mitophagy] GO:1990090 [cellular response to nerve growth factor stimulus] GO:1990418 [response to insulin-like growth factor stimulus] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005979 [regulation of glycogen biosynthetic process] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006417 [regulation of translation] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0006469 [negative regulation of protein kinase activity] GO:0006809 [nitric oxide biosynthetic process] GO:0006915 [apoptotic process] GO:0006924 [activation-induced cell death of T cells] GO:0006979 [response to oxidative stress] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007596 [blood coagulation] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009408 [response to heat] GO:0010467 [gene expression] GO:0010507 [negative regulation of autophagy] GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] GO:0010907 [positive regulation of glucose metabolic process] GO:0010951 [negative regulation of endopeptidase activity] GO:0010975 [regulation of neuron projection development] GO:0012501 [programmed cell death] GO:0015630 [microtubule cytoskeleton] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019899 [enzyme binding] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030307 [positive regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0031018 [endocrine pancreas development] GO:0031295 [T cell costimulation] GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] GO:0031982 [vesicle] GO:0031999 [negative regulation of fatty acid beta-oxidation] GO:0032079 [positive regulation of endodeoxyribonuclease activity] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032869 [cellular response to insulin stimulus] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034405 [response to fluid shear stress] GO:0035556 [intracellular signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding] GO:0043488 [regulation of mRNA stability] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045861 [negative regulation of proteolysis] GO:0046209 [nitric oxide metabolic process] GO:0046326 [positive regulation of glucose import] GO:0046777 [protein autophosphorylation] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060416 [response to growth hormone] GO:0060644 [mammary gland epithelial cell differentiation] GO:0061024 [membrane organization] GO:0070141 [response to UV-A] GO:0071889 [14-3-3 protein binding] GO:0072655 [establishment of protein localization to mitochondrion] GO:0072656 [maintenance of protein location in mitochondrion] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900182 [positive regulation of protein localization to nucleus] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901215 [negative regulation of neuron death] GO:1901976 [regulation of cell cycle checkpoint] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903599 [positive regulation of mitophagy] GO:1990090 [cellular response to nerve growth factor stimulus] GO:1990418 [response to insulin-like growth factor stimulus] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005979 [regulation of glycogen biosynthetic process] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006417 [regulation of translation] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0006469 [negative regulation of protein kinase activity] GO:0006809 [nitric oxide biosynthetic process] GO:0006915 [apoptotic process] GO:0006924 [activation-induced cell death of T cells] GO:0006979 [response to oxidative stress] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007596 [blood coagulation] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009408 [response to heat] GO:0010467 [gene expression] GO:0010507 [negative regulation of autophagy] GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] GO:0010907 [positive regulation of glucose metabolic process] GO:0010951 [negative regulation of endopeptidase activity] GO:0010975 [regulation of neuron projection development] GO:0012501 [programmed cell death] GO:0015630 [microtubule cytoskeleton] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019899 [enzyme binding] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030307 [positive regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0031018 [endocrine pancreas development] GO:0031295 [T cell costimulation] GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] GO:0031982 [vesicle] GO:0031999 [negative regulation of fatty acid beta-oxidation] GO:0032079 [positive regulation of endodeoxyribonuclease activity] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032869 [cellular response to insulin stimulus] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034405 [response to fluid shear stress] GO:0035556 [intracellular signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding] GO:0043488 [regulation of mRNA stability] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045861 [negative regulation of proteolysis] GO:0046209 [nitric oxide metabolic process] GO:0046326 [positive regulation of glucose import] GO:0046777 [protein autophosphorylation] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060416 [response to growth hormone] GO:0060644 [mammary gland epithelial cell differentiation] GO:0061024 [membrane organization] GO:0070141 [response to UV-A] GO:0071889 [14-3-3 protein binding] GO:0072655 [establishment of protein localization to mitochondrion] GO:0072656 [maintenance of protein location in mitochondrion] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900182 [positive regulation of protein localization to nucleus] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901215 [negative regulation of neuron death] GO:1901976 [regulation of cell cycle checkpoint] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903599 [positive regulation of mitophagy] GO:1990090 [cellular response to nerve growth factor stimulus] GO:1990418 [response to insulin-like growth factor stimulus] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation] GO:0001649 [osteoblast differentiation] GO:0001893 [maternal placenta development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005080 [protein kinase C binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005977 [glycogen metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005979 [regulation of glycogen biosynthetic process] GO:0006006 [glucose metabolic process] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006412 [translation] GO:0006417 [regulation of translation] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0006469 [negative regulation of protein kinase activity] GO:0006809 [nitric oxide biosynthetic process] GO:0006915 [apoptotic process] GO:0006924 [activation-induced cell death of T cells] GO:0006954 [inflammatory response] GO:0006974 [cellular response to DNA damage stimulus] GO:0006979 [response to oxidative stress] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007281 [germ cell development] GO:0007568 [aging] GO:0007596 [blood coagulation] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008637 [apoptotic mitochondrial changes] GO:0009408 [response to heat] GO:0009725 [response to hormone] GO:0010467 [gene expression] GO:0010507 [negative regulation of autophagy] GO:0010629 [negative regulation of gene expression] GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] GO:0010763 [positive regulation of fibroblast migration] GO:0010765 [positive regulation of sodium ion transport] GO:0010907 [positive regulation of glucose metabolic process] GO:0010951 [negative regulation of endopeptidase activity] GO:0010975 [regulation of neuron projection development] GO:0012501 [programmed cell death] GO:0015630 [microtubule cytoskeleton] GO:0015758 [glucose transport] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016567 [protein ubiquitination] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0021510 [spinal cord development] GO:0030030 [cell projection organization] GO:0030154 [cell differentiation] GO:0030163 [protein catabolic process] GO:0030168 [platelet activation] GO:0030212 [hyaluronan metabolic process] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030307 [positive regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0031018 [endocrine pancreas development] GO:0031295 [T cell costimulation] GO:0031641 [regulation of myelination] GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0031982 [vesicle] GO:0031999 [negative regulation of fatty acid beta-oxidation] GO:0032079 [positive regulation of endodeoxyribonuclease activity] GO:0032094 [response to food] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032287 [peripheral nervous system myelin maintenance] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032794 [GTPase activating protein binding] GO:0032869 [cellular response to insulin stimulus] GO:0032880 [regulation of protein localization] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034405 [response to fluid shear stress] GO:0035556 [intracellular signal transduction] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036064 [ciliary basal body] GO:0036294 [cellular response to decreased oxygen levels] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042593 [glucose homeostasis] GO:0042802 [identical protein binding] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding] GO:0043488 [regulation of mRNA stability] GO:0043491 [protein kinase B signaling] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045792 [negative regulation of cell size] GO:0045861 [negative regulation of proteolysis] GO:0045907 [positive regulation of vasoconstriction] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046209 [nitric oxide metabolic process] GO:0046326 [positive regulation of glucose import] GO:0046329 [negative regulation of JNK cascade] GO:0046777 [protein autophosphorylation] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051146 [striated muscle cell differentiation] GO:0051721 [protein phosphatase 2A binding] GO:0060416 [response to growth hormone] GO:0060644 [mammary gland epithelial cell differentiation] GO:0060709 [glycogen cell differentiation involved in embryonic placenta development] GO:0060716 [labyrinthine layer blood vessel development] GO:0061024 [membrane organization] GO:0070141 [response to UV-A] GO:0071260 [cellular response to mechanical stimulus] GO:0071363 [cellular response to growth factor stimulus] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0071380 [cellular response to prostaglandin E stimulus] GO:0071407 [cellular response to organic cyclic compound] GO:0071456 [cellular response to hypoxia] GO:0071889 [14-3-3 protein binding] GO:0072655 [establishment of protein localization to mitochondrion] GO:0072656 [maintenance of protein location in mitochondrion] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0097011 [cellular response to granulocyte macrophage colony-stimulating factor stimulus] GO:0097193 [intrinsic apoptotic signaling pathway] GO:0097194 [execution phase of apoptosis] GO:1900182 [positive regulation of protein localization to nucleus] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901215 [negative regulation of neuron death] GO:1901653 [cellular response to peptide] GO:1901976 [regulation of cell cycle checkpoint] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903599 [positive regulation of mitophagy] GO:1990090 [cellular response to nerve growth factor stimulus] GO:1990418 [response to insulin-like growth factor stimulus] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000060 [protein import into nucleus, translocation] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005979 [regulation of glycogen biosynthetic process] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006417 [regulation of translation] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0006469 [negative regulation of protein kinase activity] GO:0006809 [nitric oxide biosynthetic process] GO:0006915 [apoptotic process] GO:0006924 [activation-induced cell death of T cells] GO:0006979 [response to oxidative stress] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007596 [blood coagulation] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009408 [response to heat] GO:0010467 [gene expression] GO:0010507 [negative regulation of autophagy] GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] GO:0010907 [positive regulation of glucose metabolic process] GO:0010951 [negative regulation of endopeptidase activity] GO:0010975 [regulation of neuron projection development] GO:0012501 [programmed cell death] GO:0015630 [microtubule cytoskeleton] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019899 [enzyme binding] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030307 [positive regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0031018 [endocrine pancreas development] GO:0031295 [T cell costimulation] GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] GO:0031982 [vesicle] GO:0031999 [negative regulation of fatty acid beta-oxidation] GO:0032079 [positive regulation of endodeoxyribonuclease activity] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032869 [cellular response to insulin stimulus] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034405 [response to fluid shear stress] GO:0035556 [intracellular signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding] GO:0043488 [regulation of mRNA stability] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045861 [negative regulation of proteolysis] GO:0046209 [nitric oxide metabolic process] GO:0046326 [positive regulation of glucose import] GO:0046777 [protein autophosphorylation] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060416 [response to growth hormone] GO:0060644 [mammary gland epithelial cell differentiation] GO:0061024 [membrane organization] GO:0070141 [response to UV-A] GO:0071889 [14-3-3 protein binding] GO:0072655 [establishment of protein localization to mitochondrion] GO:0072656 [maintenance of protein location in mitochondrion] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900182 [positive regulation of protein localization to nucleus] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901215 [negative regulation of neuron death] GO:1901976 [regulation of cell cycle checkpoint] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903599 [positive regulation of mitophagy] GO:1990090 [cellular response to nerve growth factor stimulus] GO:1990418 [response to insulin-like growth factor stimulus] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)