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Most cancer cells showed weak to moderate cytoplasmic positivity. A few squamous cell carcinomas of cervix and ovarian cancers were strongly stained. Most cases of lymphoma, gastric, pancreatic and liver cancer were negative.
GENE INFORMATION
Gene name
ADAMTS10 (HGNC Symbol)
Synonyms
ADAM-TS10
Description
ADAM metallopeptidase with thrombospondin type 1 motif, 10 (HGNC Symbol)
Entrez gene summary
This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]