Expression of KLK3 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Kallikrein-related peptidase 3

Protein class

Cancer-related genes, Enzymes, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA000764	CAB000070

GENE INFORMATION
Gene name	KLK3 (HGNC Symbol)
Synonyms	APS, PSA
Description	Kallikrein-related peptidase 3 (HGNC Symbol)
Entrez gene summary	Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	50854915 - 50860764
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142515 (version 83.38)
Entrez gene	354
UniProt	P07288 (UniProt - Evidence at protein level)
neXtProt	NX_P07288
Antibodypedia	KLK3 antibodies

PROTEIN BROWSER

KLK3-003	KLK3-007	KLK3-010	KLK3-012	KLK3-013	KLK3-014	KLK3-015	KLK3-016	KLK3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLK3-003 ENSP00000314151 ENST00000326003	P07288 [Direct mapping] Prostate-specific antigen Q546G3 [Target identity:100%; Query identity:100%] Kallikrein 3, (Prostate specific antigen), isoform CRA_m; Prostate specific antigen; cDNA, FLJ93384, Homo sapiens kallikrein 3, (prostate specific antigen) (KLK3),transcript variant 1, mRNA Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002778 [antibacterial peptide production] GO:0004175 [endopeptidase activity] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0006508 [proteolysis] GO:0007264 [small GTPase mediated signal transduction] GO:0008236 [serine-type peptidase activity] GO:0016525 [negative regulation of angiogenesis] GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] GO:0043234 [protein complex] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	261 aa 28.7 kDa	Yes	0
KLK3-007 ENSP00000353829 ENST00000360617	P07288 [Direct mapping] Prostate-specific antigen Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002778 [antibacterial peptide production] GO:0004175 [endopeptidase activity] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0006508 [proteolysis] GO:0007264 [small GTPase mediated signal transduction] GO:0008236 [serine-type peptidase activity] GO:0016525 [negative regulation of angiogenesis] GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] GO:0043234 [protein complex] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	238 aa 26.3 kDa	Yes	0
KLK3-010 ENSP00000472907 ENST00000593997	P07288 [Direct mapping] Prostate-specific antigen Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0002778 [antibacterial peptide production] GO:0004175 [endopeptidase activity] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0006508 [proteolysis] GO:0007264 [small GTPase mediated signal transduction] GO:0008236 [serine-type peptidase activity] GO:0016525 [negative regulation of angiogenesis] GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] GO:0043234 [protein complex] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	227 aa 25.1 kDa	Yes	0
KLK3-012 ENSP00000472213 ENST00000601503	M0R1Z7 [Direct mapping] Prostate-specific antigen Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	173 aa 19.2 kDa	Yes	0
KLK3-013 ENSP00000470523 ENST00000597286	M0QZF9 [Direct mapping] Prostate-specific antigen Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	172 aa 19.1 kDa	Yes	0
KLK3-014 ENSP00000471827 ENST00000598145	M0R1F0 [Direct mapping] Prostate-specific antigen Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	262 aa 28.6 kDa	Yes	0
KLK3-015 ENSP00000471155 ENST00000595952	P07288 [Direct mapping] Prostate-specific antigen Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002778 [antibacterial peptide production] GO:0004175 [endopeptidase activity] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0006508 [proteolysis] GO:0007264 [small GTPase mediated signal transduction] GO:0008236 [serine-type peptidase activity] GO:0016525 [negative regulation of angiogenesis] GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] GO:0043234 [protein complex] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	218 aa 23.7 kDa	Yes	0
KLK3-016 ENSP00000472411 ENST00000597483	M0R294 [Direct mapping] Kallikrein 3, (Prostate specific antigen), isoform CRA_d; Prostate-specific antigen Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	195 aa 21.3 kDa	Yes	0
KLK3-201 ENSP00000483513 ENST00000617027	Q8NCW4 [Direct mapping] Prostate specific antigen; Prostate-specific antigen Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	220 aa 24.3 kDa	Yes	0