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SLC2A5

GENERAL INFORMATION

Gene name

 SLC2A5

Gene description

 Solute carrier family 2 (facilitated glucose/fructose transporter), member 5

Protein class

 Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis, duodenum, small intestine)
GTEx:Tissue enhanced (small intestine, testis)
FANTOM5:Group enriched (small intestine, colon, testis)

Protein evidence

 Evidence at protein level

Protein expression

 Expression in microvilli in cells of gastrointestinal tract and kidney, cell membranes in seminiferous ducts in testis and cytoplasm in a subset of glial cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA005449
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis, duodenum, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, colon, testis)

GENE INFORMATION

Gene name

 SLC2A5 (HGNC Symbol)

Synonyms

 GLUT5

Description

 Solute carrier family 2 (facilitated glucose/fructose transporter), member 5 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 p36.23

Chromosome location (bp)

 9035107 - 9088478

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142583 (version 83.38)

Entrez gene

 6518

UniProt

 P22732 (UniProt - Evidence at protein level)

neXtProt

 NX_P22732

Antibodypedia

 SLC2A5 antibodies

PROTEIN BROWSER
SLC2A5-001
SLC2A5-002
SLC2A5-005
SLC2A5-006
SLC2A5-007
SLC2A5-008
SLC2A5-009
SLC2A5-010
SLC2A5-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC2A5-001
ENSP00000366641
ENST00000377424
P22732 [Direct mapping]
Solute carrier family 2, facilitated glucose transporter member 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005351 [sugar:proton symporter activity]
GO:0005353 [fructose transmembrane transporter activity]
GO:0005355 [glucose transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0008645 [hexose transport]
GO:0015755 [fructose transport]
GO:0015758 [glucose transport]
GO:0015992 [proton transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0022857 [transmembrane transporter activity]
GO:0022891 [substrate-specific transmembrane transporter activity]
GO:0035428 [hexose transmembrane transport]
GO:0044281 [small molecule metabolic process]
GO:0046323 [glucose import]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071332 [cellular response to fructose stimulus]
GO:1904659 [glucose transmembrane transport]
Show all
 501 aa
55 kDa 		No >9
SLC2A5-002
ENSP00000366631
ENST00000377414
P22732 [Direct mapping]
Solute carrier family 2, facilitated glucose transporter member 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005351 [sugar:proton symporter activity]
GO:0005353 [fructose transmembrane transporter activity]
GO:0005355 [glucose transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0008645 [hexose transport]
GO:0015755 [fructose transport]
GO:0015758 [glucose transport]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0022857 [transmembrane transporter activity]
GO:0035428 [hexose transmembrane transport]
GO:0044281 [small molecule metabolic process]
GO:0046323 [glucose import]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071332 [cellular response to fructose stimulus]
GO:1904659 [glucose transmembrane transport]
Show all
 244 aa
26.5 kDa 		No 5
SLC2A5-005
ENSP00000465285
ENST00000473209
K7EJR1 [Direct mapping]
Solute carrier family 2, facilitated glucose transporter member 5
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005351 [sugar:proton symporter activity]
GO:0005353 [fructose transmembrane transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0015755 [fructose transport]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0035428 [hexose transmembrane transport]
GO:0046323 [glucose import]
GO:0055085 [transmembrane transport]
Show all
 81 aa
9.1 kDa 		Yes 0
SLC2A5-006
ENSP00000464880
ENST00000474145
K7EIT1 [Direct mapping]
Solute carrier family 2, facilitated glucose transporter member 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005351 [sugar:proton symporter activity]
GO:0005353 [fructose transmembrane transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0015755 [fructose transport]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0035428 [hexose transmembrane transport]
GO:0046323 [glucose import]
GO:0055085 [transmembrane transport]
Show all
 190 aa
20.6 kDa 		No 5
SLC2A5-007
ENSP00000467039
ENST00000484798
K7EIT1 [Direct mapping]
Solute carrier family 2, facilitated glucose transporter member 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005351 [sugar:proton symporter activity]
GO:0005353 [fructose transmembrane transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0015755 [fructose transport]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0035428 [hexose transmembrane transport]
GO:0046323 [glucose import]
GO:0055085 [transmembrane transport]
Show all
 190 aa
20.6 kDa 		No 5
SLC2A5-008
ENSP00000468590
ENST00000479813
K7EIT1 [Direct mapping]
Solute carrier family 2, facilitated glucose transporter member 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005351 [sugar:proton symporter activity]
GO:0005353 [fructose transmembrane transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0015755 [fructose transport]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0035428 [hexose transmembrane transport]
GO:0046323 [glucose import]
GO:0055085 [transmembrane transport]
Show all
 190 aa
20.6 kDa 		No 5
SLC2A5-009
ENSP00000465507
ENST00000486632
K7EIT1 [Direct mapping]
Solute carrier family 2, facilitated glucose transporter member 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005351 [sugar:proton symporter activity]
GO:0005353 [fructose transmembrane transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0015755 [fructose transport]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0035428 [hexose transmembrane transport]
GO:0046323 [glucose import]
GO:0055085 [transmembrane transport]
Show all
 190 aa
20.6 kDa 		No 5
SLC2A5-010
ENSP00000467840
ENST00000464985
K7EQI3 [Direct mapping]
Solute carrier family 2, facilitated glucose transporter member 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005351 [sugar:proton symporter activity]
GO:0005353 [fructose transmembrane transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0015755 [fructose transport]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0035428 [hexose transmembrane transport]
GO:0046323 [glucose import]
GO:0055085 [transmembrane transport]
Show all
 139 aa
15.2 kDa 		No 2
SLC2A5-011
ENSP00000465382
ENST00000487835
K7EJZ0 [Direct mapping]
Solute carrier family 2, facilitated glucose transporter member 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005351 [sugar:proton symporter activity]
GO:0005353 [fructose transmembrane transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0015755 [fructose transport]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0035428 [hexose transmembrane transport]
GO:0046323 [glucose import]
GO:0055085 [transmembrane transport]
Show all
 166 aa
18 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.