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This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Helix-turn-helix domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0001106 [RNA polymerase II transcription corepressor activity] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006607 [NLS-bearing protein import into nucleus] GO:0008267 [poly-glutamine tract binding] GO:0008270 [zinc ion binding] GO:0021549 [cerebellum development] GO:0021691 [cerebellar Purkinje cell layer maturation] GO:0021930 [cerebellar granule cell precursor proliferation] GO:0021942 [radial glia guided migration of Purkinje cell] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048755 [branching morphogenesis of a nerve] GO:0048813 [dendrite morphogenesis]
Q9P2R6 [Direct mapping] Arginine-glutamic acid dipeptide repeats protein
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Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Helix-turn-helix domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006607 [NLS-bearing protein import into nucleus] GO:0008267 [poly-glutamine tract binding] GO:0008270 [zinc ion binding] GO:0043565 [sequence-specific DNA binding]
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Helix-turn-helix domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006607 [NLS-bearing protein import into nucleus] GO:0008267 [poly-glutamine tract binding] GO:0008270 [zinc ion binding] GO:0043565 [sequence-specific DNA binding]
