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Most malignant cells showed weak to moderate cytoplasmic positivity. Papillary adenocarcinomas of thyroid along with a few ovarian, urothelial and renal cancers were strongly stained. Several malignant gliomas were negative.
GENE INFORMATION
Gene name
PADI3 (HGNC Symbol)
Synonyms
PDI3
Description
Peptidyl arginine deiminase, type III (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
