Expression of PIGK in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Phosphatidylinositol glycan anchor biosynthesis, class K

Protein class

Enzymes, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Pancreatic cancer

STAINING SUMMARY

HPA056383	HPA057040

GENE INFORMATION
Gene name	PIGK (HGNC Symbol)
Synonyms	GPI8, hGPI8
Description	Phosphatidylinositol glycan anchor biosynthesis, class K (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p31.1
Chromosome location (bp)	77088990 - 77219430
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142892 (version 83.38)
Entrez gene	10026
UniProt	Q92643 (UniProt - Evidence at protein level)
neXtProt	NX_Q92643
Antibodypedia	PIGK antibodies

PROTEIN BROWSER

PIGK-001	PIGK-002	PIGK-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIGK-001 ENSP00000359848 ENST00000370812	Q92643 [Direct mapping] GPI-anchor transamidase Show all	Enzymes Peptidases Cysteine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003756 [protein disulfide isomerase activity] GO:0003923 [GPI-anchor transamidase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006501 [C-terminal protein lipidation] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0016020 [membrane] GO:0016255 [attachment of GPI anchor to protein] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0034235 [GPI anchor binding] GO:0034394 [protein localization to cell surface] GO:0042765 [GPI-anchor transamidase complex] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	395 aa 45.3 kDa	Yes	1
PIGK-002 ENSP00000388854 ENST00000445065	B1AK81 [Direct mapping] GPI-anchor transamidase; Phosphatidylinositol glycan, class K, isoform CRA_c Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003923 [GPI-anchor transamidase activity] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0016255 [attachment of GPI anchor to protein] GO:0042765 [GPI-anchor transamidase complex] Show all	301 aa 34.3 kDa	Yes	1
PIGK-003 ENSP00000352041 ENST00000359130	A6NEM5 [Direct mapping] GPI-anchor transamidase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003923 [GPI-anchor transamidase activity] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0016255 [attachment of GPI anchor to protein] GO:0042765 [GPI-anchor transamidase complex] Show all	332 aa 37.8 kDa	Yes	0