Expression of TINAGL1 in cancer - Summary

CANCER ATLAS

Gene description

Tubulointerstitial nephritis antigen-like 1

Protein class

Enzymes, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Skin cancer

STAINING SUMMARY

HPA048695

GENE INFORMATION
Gene name	TINAGL1 (HGNC Symbol)
Synonyms	ARG1, LCN7, LIECG3, P3ECSL, TINAGRP
Description	Tubulointerstitial nephritis antigen-like 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen, a secreted glycoprotein that is recognized by antibodies in some types of immune-related tubulointerstitial nephritis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Chromosome	1
Cytoband	p35.2
Chromosome location (bp)	31576485 - 31587686
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142910 (version 83.38)
Entrez gene	64129
UniProt	Q9GZM7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9GZM7
Antibodypedia	TINAGL1 antibodies

PROTEIN BROWSER

TINAGL1-001	TINAGL1-201	TINAGL1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TINAGL1-001 ENSP00000271064 ENST00000271064	Q9GZM7 [Direct mapping] Tubulointerstitial nephritis antigen-like Show all	Enzymes Peptidases Cysteine-type peptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0006955 [immune response] GO:0007155 [cell adhesion] GO:0008234 [cysteine-type peptidase activity] GO:0016197 [endosomal transport] GO:0030247 [polysaccharide binding] GO:0031012 [extracellular matrix] GO:0043236 [laminin binding] GO:0070062 [extracellular exosome] Show all	467 aa 52.4 kDa	Yes	0
TINAGL1-201 ENSP00000395137 ENST00000457433	Q9GZM7 [Direct mapping] Tubulointerstitial nephritis antigen-like Show all	Enzymes Peptidases Cysteine-type peptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0006955 [immune response] GO:0007155 [cell adhesion] GO:0008234 [cysteine-type peptidase activity] GO:0016197 [endosomal transport] GO:0030247 [polysaccharide binding] GO:0031012 [extracellular matrix] GO:0070062 [extracellular exosome] Show all	436 aa 48.8 kDa	Yes	0
TINAGL1-202 ENSP00000445392 ENST00000537531	F6SDV2 [Direct mapping] Tubulointerstitial nephritis antigen-like; Tubulointerstitial nephritis antigen-like 1, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0007155 [cell adhesion] GO:0008234 [cysteine-type peptidase activity] Show all	362 aa 40.9 kDa	No	0