Expression of KCNA10 in cancer - Summary

CANCER ATLAS

Gene description

Potassium channel, voltage gated shaker related subfamily A, member 10

Protein class

FDA approved drug targets, Predicted membrane proteins, Voltage-gated ion channels

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA015061	CAB022564

GENE INFORMATION
Gene name	KCNA10 (HGNC Symbol)
Synonyms	Kv1.8
Description	Potassium channel, voltage gated shaker related subfamily A, member 10 (HGNC Symbol)
Entrez gene summary	Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p13.3
Chromosome location (bp)	110517251 - 110518838
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143105 (version 83.38)
Entrez gene	3744
UniProt	Q16322 (UniProt - Evidence at protein level)
neXtProt	NX_Q16322
Antibodypedia	KCNA10 antibodies

PROTEIN BROWSER

KCNA10-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNA10-001 ENSP00000358786 ENST00000369771	Q16322 [Direct mapping] Potassium voltage-gated channel subfamily A member 10 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0005216 [ion channel activity] GO:0005221 [intracellular cyclic nucleotide activated cation channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	511 aa 57.8 kDa	No	6