Expression of ALDH9A1 in cancer - Summary

CANCER ATLAS

Gene description

Aldehyde dehydrogenase 9 family, member A1

Protein class

Enzymes, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA010873

GENE INFORMATION
Gene name	ALDH9A1 (HGNC Symbol)
Synonyms	ALDH4, ALDH7, ALDH9, E3
Description	Aldehyde dehydrogenase 9 family, member A1 (HGNC Symbol)
Entrez gene summary	This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q24.1
Chromosome location (bp)	165662216 - 165698863
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143149 (version 83.38)
Entrez gene	223
UniProt	P49189 (UniProt - Evidence at protein level)
neXtProt	NX_P49189
Antibodypedia	ALDH9A1 antibodies

PROTEIN BROWSER

ALDH9A1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALDH9A1-001 ENSP00000346827 ENST00000354775	P49189 [Direct mapping] 4-trimethylaminobutyraldehyde dehydrogenase 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed B9EKV4 [Target identity:100%; Query identity:100%] Aldehyde dehydrogenase 9 family, member A1 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001822 [kidney development] GO:0001889 [liver development] GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006081 [cellular aldehyde metabolic process] GO:0008152 [metabolic process] GO:0009083 [branched-chain amino acid catabolic process] GO:0009437 [carnitine metabolic process] GO:0016491 [oxidoreductase activity] GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor] GO:0019145 [aminobutyraldehyde dehydrogenase activity] GO:0033737 [1-pyrroline dehydrogenase activity] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042136 [neurotransmitter biosynthetic process] GO:0042445 [hormone metabolic process] GO:0042803 [protein homodimerization activity] GO:0043176 [amine binding] GO:0044281 [small molecule metabolic process] GO:0045329 [carnitine biosynthetic process] GO:0047105 [4-trimethylammoniobutyraldehyde dehydrogenase activity] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	518 aa 56.3 kDa	Yes	0