Cell atlas - MGST3 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MGST3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	MGST3
Gene description	Microsomal glutathione S-transferase 3
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA053311
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA053311	CACO-2	Nucleus
	HPA053311	PC-3	Nucleus
	HPA053311	U-2 OS	Nucleus

GENE INFORMATION
Gene name	MGST3 (HGNC Symbol)
Synonyms	GST-III
Description	Microsomal glutathione S-transferase 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]
Chromosome	1
Cytoband	q24.1
Chromosome location (bp)	165630861 - 165661796
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143198 (version 83.38)
Entrez gene	4259
UniProt	O14880 (UniProt - Evidence at protein level)
neXtProt	NX_O14880
Antibodypedia	MGST3 antibodies

PROTEIN BROWSER

MGST3-001	MGST3-002	MGST3-003	MGST3-004	MGST3-005	MGST3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MGST3-001 ENSP00000356864 ENST00000367889	O14880 [Direct mapping] Microsomal glutathione S-transferase 3 A0A024R8Z1 [Target identity:100%; Query identity:100%] Microsomal glutathione S-transferase 3, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0004601 [peroxidase activity] GO:0004602 [glutathione peroxidase activity] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007165 [signal transduction] GO:0010243 [response to organonitrogen compound] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:1901687 [glutathione derivative biosynthetic process] Show all	152 aa 16.5 kDa	No	4
MGST3-002 ENSP00000356860 ENST00000367885	Q5VV89 [Direct mapping] Microsomal glutathione S-transferase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004602 [glutathione peroxidase activity] GO:0005635 [nuclear envelope] GO:0016021 [integral component of membrane] GO:0055114 [oxidation-reduction process] Show all	166 aa 18.4 kDa	No	3
MGST3-003 ENSP00000356858 ENST00000367883	Q5VV89 [Direct mapping] Microsomal glutathione S-transferase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004602 [glutathione peroxidase activity] GO:0005635 [nuclear envelope] GO:0016021 [integral component of membrane] GO:0055114 [oxidation-reduction process] Show all	166 aa 18.4 kDa	No	3
MGST3-004 ENSP00000356859 ENST00000367884	O14880 [Direct mapping] Microsomal glutathione S-transferase 3 A0A024R8Z1 [Target identity:100%; Query identity:100%] Microsomal glutathione S-transferase 3, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0004601 [peroxidase activity] GO:0004602 [glutathione peroxidase activity] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] GO:1901687 [glutathione derivative biosynthetic process] Show all	152 aa 16.5 kDa	No	4
MGST3-005 ENSP00000356863 ENST00000367888	Q5VV87 [Direct mapping] Microsomal glutathione S-transferase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004602 [glutathione peroxidase activity] GO:0005635 [nuclear envelope] GO:0016021 [integral component of membrane] GO:0055114 [oxidation-reduction process] Show all	129 aa 14.4 kDa	No	3
MGST3-201 ENSP00000487151 ENST00000627653	Q5VV89 [Direct mapping] Microsomal glutathione S-transferase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004602 [glutathione peroxidase activity] GO:0005635 [nuclear envelope] GO:0016021 [integral component of membrane] GO:0055114 [oxidation-reduction process] Show all	166 aa 18.4 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.