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ADCY10

GENERAL INFORMATION

Gene name

 ADCY10

Gene description

 Adenylate cyclase 10 (soluble)

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Group enriched (testis, liver)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous positivity in selected tissues, expression in cilia.

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA015243 , HPA017749
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (testis, liver)

GENE INFORMATION

Gene name

 ADCY10 (HGNC Symbol)

Synonyms

 HCA2, RP1-313L4.2, SAC, SACI, Sacy

Description

 Adenylate cyclase 10 (soluble) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]

Chromosome

 1

Cytoband

 q24.2

Chromosome location (bp)

 167809388 - 167914215

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143199 (version 83.38)

Entrez gene

 55811

UniProt

 Q96PN6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96PN6

Antibodypedia

 ADCY10 antibodies

PROTEIN BROWSER
ADCY10-001
ADCY10-002
ADCY10-004
ADCY10-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADCY10-001
ENSP00000356825
ENST00000367851
Q96PN6 [Direct mapping]
Adenylate cyclase type 10
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Enzymes
   ENZYME proteins
   Lyases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003351 [epithelial cilium movement]
GO:0004016 [adenylate cyclase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006171 [cAMP biosynthetic process]
GO:0007283 [spermatogenesis]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0030145 [manganese ion binding]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0031514 [motile cilium]
GO:0035556 [intracellular signal transduction]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0045177 [apical part of cell]
GO:0045178 [basal part of cell]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051117 [ATPase binding]
GO:0071241 [cellular response to inorganic substance]
GO:0071890 [bicarbonate binding]
Show all
 1610 aa
187.1 kDa 		No 4
ADCY10-002
ENSP00000356822
ENST00000367848
Q96PN6 [Direct mapping]
Adenylate cyclase type 10
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0000287 [magnesium ion binding]
GO:0003351 [epithelial cilium movement]
GO:0004016 [adenylate cyclase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006171 [cAMP biosynthetic process]
GO:0007283 [spermatogenesis]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0031514 [motile cilium]
GO:0035556 [intracellular signal transduction]
GO:0048471 [perinuclear region of cytoplasm]
GO:0071241 [cellular response to inorganic substance]
GO:0071890 [bicarbonate binding]
Show all
 1518 aa
176.6 kDa 		No 4
ADCY10-004
ENSP00000475192
ENST00000476818
U3KPS9 [Direct mapping]
Adenylate cyclase type 10
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Predicted intracellular proteins
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 73 aa
8.7 kDa 		No 0
ADCY10-005
ENSP00000441992
ENST00000545172
Q96PN6 [Direct mapping]
Adenylate cyclase type 10
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003351 [epithelial cilium movement]
GO:0004016 [adenylate cyclase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006171 [cAMP biosynthetic process]
GO:0007283 [spermatogenesis]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0031514 [motile cilium]
GO:0035556 [intracellular signal transduction]
GO:0048471 [perinuclear region of cytoplasm]
GO:0071241 [cellular response to inorganic substance]
GO:0071890 [bicarbonate binding]
Show all
 1457 aa
169.7 kDa 		No 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.