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Urothelial cancers showed moderate to strong membranous and cytoplasmic positivity. Ovarian, cervical, endometrail, lung and skin cancers displayed moderate staining in a few cases. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
PVRL4 (HGNC Symbol)
Synonyms
LNIR, nectin-4, PRR4
Description
Poliovirus receptor-related 4 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]
