Cell atlas - NUF2 - The Human Protein Atlas

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NUF2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	NUF2
Gene description	NUF2, NDC80 kinetochore complex component
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA059692
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA059692	A-431	Nucleoplasm
	HPA059692	HEK 293	Nucleus

GENE INFORMATION
Gene name	NUF2 (HGNC Symbol)
Synonyms	CDCA1, CT106, NUF2R
Description	NUF2, NDC80 kinetochore complex component (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	163266576 - 163355764
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143228 (version 83.38)
Entrez gene	83540
UniProt	Q9BZD4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZD4
Antibodypedia	NUF2 antibodies

PROTEIN BROWSER

NUF2-001	NUF2-002	NUF2-003	NUF2-004	NUF2-008	NUF2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NUF2-001 ENSP00000271452 ENST00000271452	Q9BZD4 [Direct mapping] Kinetochore protein Nuf2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000775 [chromosome, centromeric region] GO:0000777 [condensed chromosome kinetochore] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0016020 [membrane] GO:0031262 [Ndc80 complex] GO:0051301 [cell division] Show all	464 aa 54.3 kDa	No	0
NUF2-002 ENSP00000356875 ENST00000367900	Q9BZD4 [Direct mapping] Kinetochore protein Nuf2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000775 [chromosome, centromeric region] GO:0000777 [condensed chromosome kinetochore] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0016020 [membrane] GO:0031262 [Ndc80 complex] GO:0051301 [cell division] Show all	464 aa 54.3 kDa	No	0
NUF2-003 ENSP00000403252 ENST00000450453	B1AQT3 [Direct mapping] Kinetochore protein Nuf2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000775 [chromosome, centromeric region] GO:0007067 [mitotic nuclear division] Show all	145 aa 17.2 kDa	No	0
NUF2-004 ENSP00000392652 ENST00000442820	B1AQT4 [Direct mapping] Kinetochore protein Nuf2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000775 [chromosome, centromeric region] GO:0007067 [mitotic nuclear division] Show all	202 aa 23.7 kDa	No	0
NUF2-008 ENSP00000436888 ENST00000524800	E9PQC4 [Direct mapping] Kinetochore protein Nuf2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000775 [chromosome, centromeric region] GO:0007067 [mitotic nuclear division] Show all	417 aa 48.8 kDa	No	0
NUF2-009 ENSP00000433533 ENST00000534289	E9PKH1 [Direct mapping] Kinetochore protein Nuf2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000775 [chromosome, centromeric region] GO:0007067 [mitotic nuclear division] Show all	124 aa 14.4 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.