Expression of TARS2 in cancer - Summary

CANCER ATLAS

Gene description

Threonyl-tRNA synthetase 2, mitochondrial (putative)

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA028626

GENE INFORMATION
Gene name	TARS2 (HGNC Symbol)
Synonyms	FLJ12528, TARSL1
Description	Threonyl-tRNA synthetase 2, mitochondrial (putative) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the class-II aminoacyl-tRNA synthetase family. The encoded protein is a mitochondrial aminoacyl-tRNA synthetase. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 4. [provided by RefSeq, Dec 2012]
Chromosome	1
Cytoband	q21.2
Chromosome location (bp)	150487364 - 150507609
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143374 (version 83.38)
Entrez gene	80222
UniProt	Q9BW92 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BW92
Antibodypedia	TARS2 antibodies

PROTEIN BROWSER

TARS2-001	TARS2-010	TARS2-013	TARS2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TARS2-001 ENSP00000358060 ENST00000369064	Q9BW92 [Direct mapping] Threonine--tRNA ligase, mitochondrial Show all	Enzymes ENZYME proteins Ligase MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003674 [molecular_function] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004829 [threonine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006435 [threonyl-tRNA aminoacylation] GO:0010467 [gene expression] GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds] GO:0043039 [tRNA aminoacylation] GO:0070159 [mitochondrial threonyl-tRNA aminoacylation] Show all	718 aa 81 kDa	No	0
TARS2-010 ENSP00000358050 ENST00000369054	Q9BW92 [Direct mapping] Threonine--tRNA ligase, mitochondrial Show all	Enzymes ENZYME proteins Ligase MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003674 [molecular_function] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004829 [threonine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006435 [threonyl-tRNA aminoacylation] GO:0010467 [gene expression] GO:0070159 [mitochondrial threonyl-tRNA aminoacylation] Show all	588 aa 66.4 kDa	No	0
TARS2-013 ENSP00000475847 ENST00000606933	U3KQG0 [Direct mapping] Threonine--tRNA ligase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004829 [threonine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006435 [threonyl-tRNA aminoacylation] GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds] GO:0043039 [tRNA aminoacylation] Show all	636 aa 71.5 kDa	No	0
TARS2-201 ENSP00000415002 ENST00000438568	F6S7Q7 [Direct mapping] Threonine--tRNA ligase, mitochondrial Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004829 [threonine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006435 [threonyl-tRNA aminoacylation] GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds] GO:0043039 [tRNA aminoacylation] Show all	443 aa 49.9 kDa	No	0