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PIP5K1A

CANCER ATLAS

Gene description

 Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha

Protein class

 Cancer-related genes, Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029366

GENE INFORMATION

Gene name

 PIP5K1A

Synonyms

Description

 Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 151197949 - 151249536

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143398 (version 83.38)

Entrez gene

 8394

UniProt

 Q99755 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99755

Antibodypedia

 PIP5K1A antibodies

PROTEIN BROWSER
PIP5K1A-001
PIP5K1A-002
PIP5K1A-003
PIP5K1A-004
PIP5K1A-011
PIP5K1A-014
PIP5K1A-015
PIP5K1A-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PIP5K1A-001
ENSP00000271663
ENST00000349792
Q99755 [Direct mapping]
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005847 [mRNA cleavage and polyadenylation specificity factor complex]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006644 [phospholipid metabolic process]
GO:0006650 [glycerophospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006909 [phagocytosis]
GO:0007165 [signal transduction]
GO:0008654 [phospholipid biosynthetic process]
GO:0016307 [phosphatidylinositol phosphate kinase activity]
GO:0016308 [1-phosphatidylinositol-4-phosphate 5-kinase activity]
GO:0016477 [cell migration]
GO:0016607 [nuclear speck]
GO:0019900 [kinase binding]
GO:0030027 [lamellipodium]
GO:0030216 [keratinocyte differentiation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032587 [ruffle membrane]
GO:0044281 [small molecule metabolic process]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0048041 [focal adhesion assembly]
GO:0060326 [cell chemotaxis]
GO:0072661 [protein targeting to plasma membrane]
GO:0090630 [activation of GTPase activity]
GO:0097178 [ruffle assembly]
Show all
 549 aa
61.2 kDa 		No 0
PIP5K1A-002
ENSP00000357885
ENST00000368890
Q99755 [Direct mapping]
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005847 [mRNA cleavage and polyadenylation specificity factor complex]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006644 [phospholipid metabolic process]
GO:0006650 [glycerophospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006909 [phagocytosis]
GO:0007165 [signal transduction]
GO:0008654 [phospholipid biosynthetic process]
GO:0016307 [phosphatidylinositol phosphate kinase activity]
GO:0016308 [1-phosphatidylinositol-4-phosphate 5-kinase activity]
GO:0016477 [cell migration]
GO:0016607 [nuclear speck]
GO:0019900 [kinase binding]
GO:0030027 [lamellipodium]
GO:0030216 [keratinocyte differentiation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032587 [ruffle membrane]
GO:0044281 [small molecule metabolic process]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0048041 [focal adhesion assembly]
GO:0060326 [cell chemotaxis]
GO:0072661 [protein targeting to plasma membrane]
GO:0090630 [activation of GTPase activity]
GO:0097178 [ruffle assembly]
Show all
 500 aa
56.1 kDa 		No 0
PIP5K1A-003
ENSP00000357883
ENST00000368888
Q99755 [Direct mapping]
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005847 [mRNA cleavage and polyadenylation specificity factor complex]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006644 [phospholipid metabolic process]
GO:0006650 [glycerophospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006909 [phagocytosis]
GO:0007165 [signal transduction]
GO:0008654 [phospholipid biosynthetic process]
GO:0010761 [fibroblast migration]
GO:0016307 [phosphatidylinositol phosphate kinase activity]
GO:0016308 [1-phosphatidylinositol-4-phosphate 5-kinase activity]
GO:0016477 [cell migration]
GO:0016607 [nuclear speck]
GO:0019900 [kinase binding]
GO:0030027 [lamellipodium]
GO:0030216 [keratinocyte differentiation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032587 [ruffle membrane]
GO:0044281 [small molecule metabolic process]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0048041 [focal adhesion assembly]
GO:0060326 [cell chemotaxis]
GO:0072661 [protein targeting to plasma membrane]
GO:0090630 [activation of GTPase activity]
GO:0097178 [ruffle assembly]
Show all
 562 aa
62.6 kDa 		No 0
PIP5K1A-004
ENSP00000414632
ENST00000418435
A6PW58 [Direct mapping]
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 86 aa
9.4 kDa 		No 0
PIP5K1A-011
ENSP00000401228
ENST00000447555
A2A5X0 [Direct mapping]
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 101 aa
11.1 kDa 		No 0
PIP5K1A-014
ENSP00000392780
ENST00000424999
A6PW56 [Direct mapping]
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 41 aa
4 kDa 		No 0
PIP5K1A-015
ENSP00000386432
ENST00000409426
A6PW57 [Direct mapping]
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0016307 [phosphatidylinositol phosphate kinase activity]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
Show all
 550 aa
61.3 kDa 		No 0
PIP5K1A-016
ENSP00000415648
ENST00000441902
Q99755 [Direct mapping]
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005847 [mRNA cleavage and polyadenylation specificity factor complex]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006644 [phospholipid metabolic process]
GO:0006650 [glycerophospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006909 [phagocytosis]
GO:0007165 [signal transduction]
GO:0008654 [phospholipid biosynthetic process]
GO:0016307 [phosphatidylinositol phosphate kinase activity]
GO:0016308 [1-phosphatidylinositol-4-phosphate 5-kinase activity]
GO:0016477 [cell migration]
GO:0016607 [nuclear speck]
GO:0019900 [kinase binding]
GO:0030027 [lamellipodium]
GO:0030216 [keratinocyte differentiation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032587 [ruffle membrane]
GO:0044281 [small molecule metabolic process]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0048041 [focal adhesion assembly]
GO:0060326 [cell chemotaxis]
GO:0072661 [protein targeting to plasma membrane]
GO:0090630 [activation of GTPase activity]
GO:0097178 [ruffle assembly]
Show all
 522 aa
58.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.